Inflammation: An Equal-Opportunity Process
- David B. Sachar
- … show all 1 hide
Today’s media are saturated with alarms about the dangers of obesity. We are warned about the impending epidemic of diabetes, heart disease, cancer, stroke, and a litany of other ailments. But who would have ever imagined that Crohn’s disease would land on this list of horrors?
In this issue of Digestive Diseases and Sciences, investigators from St. George’s Medical School in London suggest that obesity may play a role in the pathogenesis of Crohn’s disease (CD) . They arrived at this conclusion via observations on a series of 524 patients with inflammatory bowel disease (IBD) and 480 community controls. The crux of their findings was that obesity at time of diagnosis was approximately twice as common among Crohn’s disease patients as among ulcerative colitis (UC) patients, and about three times as common among CD patients diagnosed in later life (ages 50 to 70 years) as among age-matched community controls.
One’s first reaction upon reading these conclusions might be that they are c
- Mendall MA, Genasekera AV, Biku JJ, Kumar DA. Is obesity a risk factor for Crohn’s disease? Dig Dis Sci. 2011;56:INSERT.
- Peyrin-Biroulet L, Chamaillard M, Gonzalez F, et al. Mesenteric fat in Crohn’s disease: A pathogenic hallmark or an innocent bystander? Gut. 2007;56:577–583. CrossRef
- Salomon P, Pizzimenti A, Panja A, Reisman A, Mayer L. The expression and regulation of class II antigens in normal and inflammatory bowel disease peripheral blood monoctyes and intestinal epithelium. Autoimmunity. 1991;9:141–149. CrossRef
- Shkoda A, Ruiz PA, Kim SC, et al. Intestinal epithelial cell signaling and host-derived negative regulators under chronic inflammation. Inflamm Bowel Dis. 2006;12:S23. CrossRef
- Fiocchi C, Ina K, Danese S, Leite AZ, Vogel JD. Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases. Adv Exp Med Biol. 2006;579:168–176. CrossRef
- Collins SM. Stress and the gastrointestinal tract. IV. Modulation of intestinal inflammation by stress: Basic mechanisms and clinical relevance. Am J Physiol. 2001;280:G315–G318.
- Pinchuk IV, Mifflin RC, Saada JI, Powell DW. Intestinal mesenchymal cells. Curr Gastroenterol Rep. 2010;12:310–318. CrossRef
- Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Ann Rev Physiol. 2010. Epub ahead of print.
- Trayhum P, Drevon CA, Eckel J. Secreted proteins from adipose tissue and skeletal muscle-adipokines, myokines, and adipose/muscle cross-talk. Arch Physiol Biochem. 2010. Epub ahead of print.
- Desreumaux P, Ernst O, Geboes K, et al. Inflammatory alterations in mesenteric adipose tissue in Crohn’s disease. Gastroenterology. 1999;117:73–81. CrossRef
- Konishi M, Nakamura H, Miwa H, Chambon P, Ornitz DM, Itoh N. Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue. Mol Cell Endocrinol. 2008;287:13–19. CrossRef
- Inflammation: An Equal-Opportunity Process
Digestive Diseases and Sciences
Volume 56, Issue 3 , pp 629-630
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Industry Sectors
- David B. Sachar (1)
- Author Affiliations
- 1. Mount Sinai School of Medicine, New York, NY, USA