Validation of ICD-9-CM Diagnostic Codes for Inflammatory Bowel Disease Among Veterans
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- Thirumurthi, S., Chowdhury, R., Richardson, P. et al. Dig Dis Sci (2010) 55: 2592. doi:10.1007/s10620-009-1074-z
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Inflammatory bowel disease (IBD) is well described among young whites and less so among the elderly and non-whites. Population-level data is required to assess outcomes among minority groups.
To validate diagnostic codes for IBD from the Department of Veterans Affairs.
National databases were used to identify local patients with Crohn’s disease (CD) and ulcerative colitis (UC), the extra-intestinal manifestations and surgical procedures associated with IBD. Diagnosis was confirmed by manual chart abstraction. Multivariable logistic regression was used to derive diagnostic algorithms for CD and UC, which were then validated in an independent cohort.
The test cohort of 3,827 patients (1,316 potential cases, 2,511 random controls) was predominantly male (94%), white (56%), and of age of 58 (standard deviation 15). The positive predictive value (PPV) of CD codes was superior (88–100%) to UC (50–93%). The accuracy of extra-intestinal manifestations and surgeries was poor (PPV 0–29%). ICD-9-CM code 555.x without 560.9 had a PPV of 91% for CD in the validation cohort. Code 556.x with age, gender, and race factors was highly predictive of UC (c-statistic 0.9, PPV of 81%).
VA administrative data can diagnose elderly and non-white patients with IBD.
KeywordsICD-9-CM codeUlcerative colitisCrohn’s diseaseValidation studiesVeteransElderlyPositive predictive value
Department of Veterans Affairs
Patient treatment file
Outpatient care file
Veterans Affairs Pharmacy Benefits Management
Beneficiary identification and records locator subsystem death file
Michael E. DeBakey VA Medical Center
Inflammatory bowel disease
Current procedural terminology
International classification of diseases, ninth revision, clinical modification
Positive predictive value