Digestive Diseases and Sciences

, Volume 55, Issue 3, pp 716–723

Intestinal Permeability in Irritable Bowel Syndrome Patients: Effects of NSAIDs

  • Angèle P. M. Kerckhoffs
  • Louis M. A. Akkermans
  • Martin B. M. de Smet
  • Marc G. H. Besselink
  • Falco Hietbrink
  • Imke H. Bartelink
  • Wim B. Busschers
  • Melvin Samsom
  • Willem Renooij
Original Article

DOI: 10.1007/s10620-009-0765-9

Cite this article as:
Kerckhoffs, A.P.M., Akkermans, L.M.A., de Smet, M.B.M. et al. Dig Dis Sci (2010) 55: 716. doi:10.1007/s10620-009-0765-9

Abstract

Intestinal permeability and the effect of NSAIDs on permeability were investigated in 14 irritable bowel syndrome (IBS) patients and 15 healthy subjects. In the study, 24-h urinary recoveries of orally administered polyethylene glycols (PEGs 400, 1500, and 4000) were not significantly different in healthy subjects and IBS patients before or after NSAID ingestion. Lactulose mannitol ratios in healthy subjects and IBS patients were not significantly different. Only time-dependent monitoring of PEG excretion showed that NSAIDs enhanced intestinal permeability for PEG 4000 in healthy subjects (P = 0.050) and for PEGs 400, 1500, and 4000 in IBS patients (P = 0.012, P = 0.041, and P = 0.012, respectively). These results show that intestinal permeability in IBS patients is not different from that in healthy subjects; NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents.

Keywords

NSAIDsPolyethylene glycolPEGIntestinal permeabilityIBS

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Angèle P. M. Kerckhoffs
    • 1
  • Louis M. A. Akkermans
    • 2
  • Martin B. M. de Smet
    • 2
  • Marc G. H. Besselink
    • 2
  • Falco Hietbrink
    • 2
  • Imke H. Bartelink
    • 3
  • Wim B. Busschers
    • 4
  • Melvin Samsom
    • 1
  • Willem Renooij
    • 2
  1. 1.Gastrointestinal Research Unit of Departments of GastroenterologyUniversity Medical Center UtrechtUtrechtThe Netherlands
  2. 2.Gastrointestinal Research Unit of Departments of SurgeryUniversity Medical Center UtrechtUtrechtThe Netherlands
  3. 3.Department of PharmacyUniversity Medical Center UtrechtUtrechtThe Netherlands
  4. 4.Center for BiostatisticsUtrecht UniversityUtrechtThe Netherlands