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Helicobacter pylori Isolated from a Patient with Ménétrier’s Disease Increases Hepatocyte Growth Factor mRNA Expression in Gastric Fibroblasts: Comparison with Helicobacter pylori Isolated from Other Gastric Diseases

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An Erratum to this article was published on 31 March 2012

Abstract

Ménétrier’s disease has been reported to be associated with Helicobacter pylori infection. The aim of this study was to investigate the genetic characteristics of various virulence factors and cytokine expression profiles in Helicobacter pylori isolated from patients with Ménétrier’s disease. The genotyping of virulence factors was accomplished by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). Induction of various cytokines in MKN45 cells or gastric fibroblasts by Helicobacter pylori stimulus was measured by real-time reverse transcription-PCR. We found that the Helicobacter pylori strain isolated from a patient with Ménétrier’s disease was different from other strains in the MseI-RFLP pattern of the ureC gene. Helicobacter pylori isolated from a patient with Ménétrier’s disease showed the highest hepatocyte growth factor (HGF) and TNF-α mRNA expressions from gastric fibroblasts, and the highest TNF-α expression from MKN45 cells. The results in this study suggest that the difference in cytokine production, depending on the difference in bacteria components, plays an important role in the development of Ménétrier’s disease.

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Authors and Affiliations

  1. Department of Gastroenterology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi City, Osaka, 570-8540, Japan

    Takeshi Ishikawa, Mika Okita, Yutaka Isozaki, Yasuyuki Nagao & Hirokazu Oyamada

  2. Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Takashi Ando, Nami Nakabe, Haruki Kato, Satoshi Kokura, Yuji Naito & Toshikazu Yoshikawa

  3. Institute of Bio-Response Informatics, Kyoto, Japan

    Hiroshi Obayashi

  4. Department of Central Laboratory, Matsushita Memorial Hospital, Moriguchi City, Japan

    Yoshihiro Nakajima

  5. Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Norimasa Yoshida

Authors
  1. Takeshi Ishikawa
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  2. Takashi Ando
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  3. Hiroshi Obayashi
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  14. Toshikazu Yoshikawa
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Correspondence to Takeshi Ishikawa.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10620-012-2143-2.

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Ishikawa, T., Ando, T., Obayashi, H. et al. Helicobacter pylori Isolated from a Patient with Ménétrier’s Disease Increases Hepatocyte Growth Factor mRNA Expression in Gastric Fibroblasts: Comparison with Helicobacter pylori Isolated from Other Gastric Diseases. Dig Dis Sci 53, 1785–1791 (2008). https://doi.org/10.1007/s10620-007-0070-4

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  • DOI: https://doi.org/10.1007/s10620-007-0070-4

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