Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2387–2395

The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty Liver Disease: A Pilot Study

Authors

  • Carmela Loguercio
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
    • Via Alcide De Gasperi 80
  • Marco Trappoliere
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Concetta Tuccillo
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Ilario de Sio
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Agnese Di Leva
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Marco Niosi
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Mauro Valeriano D’Auria
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Rita Capasso
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Camillo Del Vecchio Blanco
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
  • Real Sud Group
    • Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of GastroenterologySecond University of Naples
Original Paper

DOI: 10.1007/s10620-006-9703-2

Cite this article as:
Loguercio, C., Federico, A., Trappoliere, M. et al. Dig Dis Sci (2007) 52: 2387. doi:10.1007/s10620-006-9703-2

Abstract

Oxidative stress leads to chronic liver damage. Silybin has been conjugated with vitamin E and phospholipids to improve its antioxidant activity. Eighty-five patients were divided into 2 groups: those affected by nonalcoholic fatty liver disease (group A) and those with HCV-related chronic hepatitis associated with nonalcoholic fatty liver disease (group B), nonresponders to treatment. The treatment consisted of silybin/vitamin E/phospholipids. After treatment, group A showed a significant reduction in ultrasonographic scores for liver steatosis. Liver enzyme levels, hyperinsulinemia, and indexes of liver fibrosis showed an improvement in treated individuals. A significant correlation among indexes of fibrosis, body mass index, insulinemia, plasma levels of transforming growth factor-β, tumor necrosis factor-α, degree of steatosis, and γ-glutamyl transpeptidase was observed. Our data suggest that silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage.

Keywords

SilybinNonalcoholic fatty liver diseaseOxidative stressHepatitis C virus

Copyright information

© Springer Science+Business Media, LLC 2006