Original Paper

Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2387-2395

The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty Liver Disease: A Pilot Study

  • Carmela LoguercioAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Alessandro FedericoAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of NaplesVia Alcide De Gasperi 80 Email author 
  • , Marco TrappoliereAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Concetta TuccilloAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Ilario de SioAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Agnese Di LevaAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Marco NiosiAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Mauro Valeriano D’AuriaAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
  • , Rita CapassoAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
    • , Camillo Del Vecchio BlancoAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples
    • , Real Sud GroupAffiliated withInteruniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples

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Abstract

Oxidative stress leads to chronic liver damage. Silybin has been conjugated with vitamin E and phospholipids to improve its antioxidant activity. Eighty-five patients were divided into 2 groups: those affected by nonalcoholic fatty liver disease (group A) and those with HCV-related chronic hepatitis associated with nonalcoholic fatty liver disease (group B), nonresponders to treatment. The treatment consisted of silybin/vitamin E/phospholipids. After treatment, group A showed a significant reduction in ultrasonographic scores for liver steatosis. Liver enzyme levels, hyperinsulinemia, and indexes of liver fibrosis showed an improvement in treated individuals. A significant correlation among indexes of fibrosis, body mass index, insulinemia, plasma levels of transforming growth factor-β, tumor necrosis factor-α, degree of steatosis, and γ-glutamyl transpeptidase was observed. Our data suggest that silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage.

Keywords

Silybin Nonalcoholic fatty liver disease Oxidative stress Hepatitis C virus