Original Article

Digestive Diseases and Sciences

, Volume 52, Issue 3, pp 732-736

First online:

Pegylated Interferon and Ribavirin Failures: Is Retreatment an Option?

  • Rekha CheruvattathAffiliated withTransplant Medicine, Mayo Clinic
  • , Marianne J. RosatiAffiliated withTransplant Medicine, Mayo Clinic
  • , Manjushree GautamAffiliated withTransplant Medicine, Mayo Clinic
  • , Hugo E. VargasAffiliated withTransplant Medicine, Mayo Clinic
  • , Jorge RakelaAffiliated withTransplant Medicine, Mayo Clinic
  • , Vijayan BalanAffiliated withTransplant Medicine, Mayo ClinicDivision of Gastroenterology and Hepatology, Transplant Medicine, Mayo Clinic

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Currently, there are limited therapeutic options available for chronic hepatitis C (HCV) patients who fail treatment with peginterferon α (PEG IFN) + ribavirin (RBV). An option is retreatment with a second course PEG-IFN + RBV. However, the virologic clearance with this option is unknown. Thus, we evaluated the outcome of our cohort of patients with chronic HCV who achieved a sustained viral response when retreated with PEG IFN plus RBV after having no response to an initial course of PEG IFN plus RBV. Nonresponse to treatment was defined as failure to achieve an early virologic response by week 12 or presence of detectable HCV RNA at week 24 or after completion of PEG-IFN + RBV therapy. Twenty patients (12 [60%] men; 8 [40%] women) were treated with PEG IFN α-2b plus RBV and PEG IFN α-2a plus RBV. The mean age of the patients was 50 years, 85% were white, 95% had genotype 1, and 35% had cirrhosis. Prior to the first course of PEG IFN plus RBV, 12 (60%) of 20 patients had no prior treatment for Hepatitis C. After the second course of PEG IFN plus RBV, 2 (10%) of 20 patients achieved a sustained virologic response. These results suggest marginal benefit of retreatment of patients with chronic HCV with another course of PEG IFN plus RBV after they have not responded to an initial course of PEG IFN plus RBV.


Hepatitis C Chronic Interferon Peginterferon Retreatment Ribavirin