Digestive Diseases and Sciences

, Volume 51, Issue 12, pp 2165–2169

Medication-Taking Behavior in a Cohort of Patients with Inflammatory Bowel Disease

  • Isabel Bernal
  • Eugeni Domènech
  • Esther Garcia-Planella
  • Laura Marín
  • Míriam Mañosa
  • Mercè Navarro
  • Eduard Cabré
  • Miquel A. Gassull
Original Article

DOI: 10.1007/s10620-006-9444-2

Cite this article as:
Bernal, I., Domènech, E., Garcia-Planella, E. et al. Dig Dis Sci (2006) 51: 2165. doi:10.1007/s10620-006-9444-2

Abstract

Recent studies have shown a low adherence rate to maintenance treatment in patients with inflammatory bowel disease (IBD). We sought to assess the medication-taking behavior in a cohort of patients with IBD. We prospectively included IBD patients from the outpatient clinic who agreed to answer a questionnaire about prescribed treatment and adherence. Physicians registered clinical data including prescribed medications. Two hundred fourteen patients (115 Crohn's disease/99 ulcerative colitis) were included. The most prescribed medications were oral mesalazine (56.5%) and immunomodulators (41.1%). Forty-three percent of patients admitted to occasionally forgetting to take their medication but only 7.5% of them did it voluntary. Oral mesalazine and azathioprine were the drugs with the poorest compliance, with nonadherence rates of 45% and 25% of the total prescribed doses, respectively. The only factor associated with a better adherence was a more complicated course of the disease—steroid dependency, steroid refractoriness, need for infliximab treatment, hospitalization, or surgery (P=.02). Twenty percent of patients admitted to self-medicating. An important proportion of patients with IBD admit to forget some doses of the prescribed medication in the setting of a specialized unit of a referral centre.

Keywords

Inflammatory bowel diseaseUlcerative colitisCrohn's diseaseAdherenceComplianceSelf-medicationMesalazineAzathioprine

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Isabel Bernal
    • 1
  • Eugeni Domènech
    • 1
  • Esther Garcia-Planella
    • 1
  • Laura Marín
    • 1
  • Míriam Mañosa
    • 1
  • Mercè Navarro
    • 1
  • Eduard Cabré
    • 1
  • Miquel A. Gassull
    • 1
  1. 1.Gastroenterology DepartmentHospital Universitari Germans Trias i PujolBadalonaSpain