, Volume 52, Issue 5, pp 1310-1312

Celiac Disease Is Not Associated with Chronic Hepatitis C

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Introduction

Celiac disease (CD) is characterized by malabsorption due to a local immune response to dietary gluten against the mucosa of the small intestine in genetically predisposed patients bearing the human leukocyte antigen (HLA) DR3-DQ2 or DR4-DQ8. CD has a wide spectrum of gastrointestinal and extraintestinal manifestations, including dermatitis herpetiformis, type 1 diabetes mellitus, and autoimmune thyroiditis [1]. It has been hypothesized that hepatitis C virus (HCV) may trigger immunologic gluten intolerance in susceptible people [2]. However, this assumption is still a matter of debate. Recently, we diagnosed four patients having both CD and chronic hepatitis C, three of them having a well-defined route of transmission, suggesting that there is no obvious link between the two diseases.

Case reports

Patient 1

A 45-year-old woman had been suffering from CD for a long time and treated with a gluten-free diet. She had been transfused at the age of 20 due to ferriprive anemia. Chro

Association Nationale des Hépato-gastroentérologues des Hôpitaux Généraux”