Original Research


, Volume 67, Issue 1, pp 135-143

First online:

Antimicrobial and antioxidant activities with acute toxicity, cytotoxicity and mutagenicity of Cystoseira compressa (Esper) Gerloff & Nizamuddin from the coast of Urla (Izmir, Turkey)

  • Adem GünerAffiliated withDepartment of Biology, Faculty of Science, Ege University
  • , Çinel KöksalAffiliated withCenter for Drug Research and Development and Pharmacokinetic Applications, Ege University
  • , Şüra Baykan ErelAffiliated withDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Ege University
  • , Hüsniye KayalarAffiliated withDepartment of Pharmacognosy, Faculty of Pharmacy, Ege University
  • , Ayşe NalbantsoyAffiliated withDepartment of Bioengineering, Faculty of Engineering, Ege University
  • , Atakan SukatarAffiliated withDepartment of Biology, Faculty of Science, Ege University
  • , N. Ülkü Karabay YavaşoğluAffiliated withDepartment of Biology, Faculty of Science, Ege University Email author 

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The aim of the study was to evaluate the biological activities with toxic properties of the methanol, hexane, and chloroform extracts of Cystoseira compressa (Esper) Gerloff & Nizamuddin from the Coast of Urla in the Aegean Sea. The extracts of C. compressa were tested for their antimicrobial and antioxidant activities in this study. Cytotoxic and mutagenic potentials of the extracts were also evaluated using cell culture and mutagenicity assays. Hexane extract was found to have higher total flavonoid and phenolic contents than the other extracts and exerted higher antioxidant activity than other extracts. All extracts exhibited moderate antimicrobial activity against tested microorganisms (minimum inhibitory concentration ranges are 32–256 μg/mL). The results indicated that the extracts had no significant cytotoxic activity against human hepatocellular carcinoma Hep 3B cell line in all treated concentrations (5–50 μg/mL) and did not show mutagenicity in the Ames test. Lethality was not observed among mice treated with oral doses of the extracts. In conclusion, results of investigations indicate that brown alga C. compressa is a natural source of antioxidant. It has moderate antimicrobial activities with no toxicity.


Cystoseira compressa Antioxidant activity Antimicrobial activity Acute toxicity Cytotoxicity Mutagenicity