Original Research

Cytotechnology

, Volume 66, Issue 2, pp 251-257

Open Access This content is freely available online to anyone, anywhere at any time.

Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats

  • Gokhan BayramogluAffiliated withScience and Arts Faculty, Department of Biology, Artvin Coruh University Email author 
  • , Hakan SenturkAffiliated withScience and Arts Faculty, Department of Biology, Eskisehir Osmangazi University
  • , Aysegul BayramogluAffiliated withScience and Arts Faculty, Department of Biology, Artvin Coruh University
  • , Mustafa UyanogluAffiliated withScience and Arts Faculty, Department of Biology, Eskisehir Osmangazi University
  • , Suat ColakAffiliated withScience and Arts Faculty, Department of Biology, Artvin Coruh University
  • , Ayse OzmenAffiliated withScience and Arts Faculty, Department of Biology, Hitit University
  • , Durdane KolankayaAffiliated withScience Faculty, Department of Biology, Hacettepe University

Abstract

Little is known about the protective effects of carvacrol on the symptoms of streptozotocin induced diabetes in rats. Hence, this present study was designed to evaluate the protective effect of the strong antioxidant, carvacrol, on the symptoms of streptozotocin induced diabetes in rats. Carvacrol at the doses of 25 and 50 mg/kg body weight were orally administered to diabetic rats for a period of 7 days after the onset of diabetes. Food-water intake and body weight changes were daily recorded. Biochemical parameters such as serum glucose, insulin, total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were measured. Although treatment of diabetic rats with oral administration of carvacrol resulted in a slight reduction in serum glucose level and significant reduction in serum total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase in comparison with diabetic control rats, there were no significant differences in serum insulin levels, food-water intake values and body weight changes. Despite the inadequacy of carvacrol on diabetes treatments, it was determined to have at least a partially protective role on liver enzymes.

Keywords

Carvacrol Diabetes Streptozotocin Rat Liver