A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (1), together with four known compounds, 5,6-dehydrokawain (2), dihydro-5,6-dehydrokawain (3), (E)-labda-8(17),12-diene-15,16-dial (4), and quercetin (5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (4) and quercetin (5) exhibited potent inhibition, with IC50 values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O −2 ) generation.
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Acknowledgment
This research was supported by a grant from the Ministry of Science and Technology, Taiwan (NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen. This work was also supported by Tajen University Grant 103002.
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 36–38.
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Chen, JJ., Liao, HR., Chen, KS. et al. A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet . Chem Nat Compd 53, 40–43 (2017). https://doi.org/10.1007/s10600-017-1906-6
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DOI: https://doi.org/10.1007/s10600-017-1906-6