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Synthesis and Evaluation of Several 3,4-Seco-Derivatives of Myricerone as Endothelin Receptor Antagonists

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Chemistry of Natural Compounds Aims and scope

3,4-Seco-derivatives of myricerone were prepared by the Baeyer–Villiger oxidation of myricerone, and their structures were elucidated based on NMR and MS analyses. The synthesized compounds were evaluated as endothelin receptor antagonists and exhibited significant binding affinity for the ETA receptor.

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Acknowledgment

This project was supported financially by the Higher Education Department of the Liaoning Province Research Foundation (Grant No. LJQ2013034). The project is sponsored by Liaoning BaiQianWan Talents Program (Grant No. 2013921057) and the Science and Technology Department of Liaoning Province Science Foundation (Grant 2010226003).

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Authors and Affiliations

  1. Center of Separation Technology, School of Chemical Engineering, University of Science and Technology Liaoning, 114051, Liaoning, Anshan, P. R. China

    Junyi Hu, Chengfei Liu, Yingqian Xu, Yun Gao & Guoyong Xiao

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  1. Junyi Hu
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  2. Chengfei Liu
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  3. Yingqian Xu
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  4. Yun Gao
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  5. Guoyong Xiao
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Corresponding author

Correspondence to Yingqian Xu.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2014, pp. 407–409.

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Hu, J., Liu, C., Xu, Y. et al. Synthesis and Evaluation of Several 3,4-Seco-Derivatives of Myricerone as Endothelin Receptor Antagonists. Chem Nat Compd 50, 470–472 (2014). https://doi.org/10.1007/s10600-014-0989-6

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  • DOI: https://doi.org/10.1007/s10600-014-0989-6

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