Chemistry of Natural Compounds

, Volume 43, Issue 1, pp 19–23

Modified coumarins. 27. Ssynthesis and antioxidant activity of 3-substituted 5,7-dihydroxy-4-methylcoumarins

  • M. M. Garazd
  • O. V. Muzychka
  • A. I. Vovk
  • I. V. Nagorichna
  • A. S. Ogorodniichuk
Article

DOI: 10.1007/s10600-007-0055-8

Cite this article as:
Garazd, M.M., Muzychka, O.V., Vovk, A.I. et al. Chem Nat Compd (2007) 43: 19. doi:10.1007/s10600-007-0055-8

Abstract

Amides of 5,7-dihydroxy-4-methylcoumaryl-3-ylacetic acid were synthesized by the activated ester method using N-hydroxysuccinimide and diisopropylcarbodiimide or by reaction with N,N-carbonylimidazole. The reactivity of 3-substituted 5,7-dihydroxy-4-methylcoumarins toward 2,2-diphenyl-1-picrylhydrazyl and superoxide radical was analyzed. The effect of the synthesized compounds on xanthineoxidase activity was studied.

Key words

coumarinsantioxidantsxanthineoxidaseactive oxygen species

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • M. M. Garazd
    • 1
  • O. V. Muzychka
    • 1
  • A. I. Vovk
    • 1
  • I. V. Nagorichna
    • 1
  • A. S. Ogorodniichuk
    • 1
  1. 1.Institute of Bioorganic and Petroleum ChemistryNational Academy of Sciences of UkraineKievUkraine