Article

Chemistry of Natural Compounds

, Volume 43, Issue 1, pp 19-23

Modified coumarins. 27. Ssynthesis and antioxidant activity of 3-substituted 5,7-dihydroxy-4-methylcoumarins

  • M. M. GarazdAffiliated withInstitute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine
  • , O. V. MuzychkaAffiliated withInstitute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine
  • , A. I. VovkAffiliated withInstitute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine
  • , I. V. NagorichnaAffiliated withInstitute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine
  • , A. S. OgorodniichukAffiliated withInstitute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine

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Abstract

Amides of 5,7-dihydroxy-4-methylcoumaryl-3-ylacetic acid were synthesized by the activated ester method using N-hydroxysuccinimide and diisopropylcarbodiimide or by reaction with N,N-carbonylimidazole. The reactivity of 3-substituted 5,7-dihydroxy-4-methylcoumarins toward 2,2-diphenyl-1-picrylhydrazyl and superoxide radical was analyzed. The effect of the synthesized compounds on xanthineoxidase activity was studied.

Key words

coumarins antioxidants xanthineoxidase active oxygen species