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Microwave-assisted one-pot synthesis of some new flavonols by modified Algar–Flynn–Oyamada reaction and their antimicrobial activity

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Chemistry of Heterocyclic Compounds Aims and scope

A new series of 3-hydroxy-2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]-4H-chromen-4-ones has been synthesized from substituted 2-hydroxyacetophenones and 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde using NaOH and H2O2 by modified Algar–Flynn–Oyamada reaction under conventional and microwave irradiation conditions. In this method flavonols are synthesized without isolating chalcones in good yields (80–85%). The structures of the compounds were established on the basis of IR, 1H, 13C NMR and mass spectral and elemental analysis data. The synthesized compounds were screened for their antibacterial and antifungal activities.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Dongamanti Ashok, Mohsin Ahmed Kifah & Bommidi Vijaya Lakshmi

  2. Department of Chemistry, Satavahana University, Karimnagar, Telangana, 505001, India

    Madderla Sarasija

  3. Regional Agricultural Research Station, ANGRAU, Tirupati, 517502, India

    Shaik Adam

Authors
  1. Dongamanti Ashok
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  2. Mohsin Ahmed Kifah
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  3. Bommidi Vijaya Lakshmi
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  4. Madderla Sarasija
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  5. Shaik Adam
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Corresponding author

Correspondence to Dongamanti Ashok.

Additional information

Supplementary information file to this article containing IR, 1H, 13C NMR and mass spectra of the synthesized compounds is available online at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(3), 172–176

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Ashok, D., Kifah, M.A., Lakshmi, B.V. et al. Microwave-assisted one-pot synthesis of some new flavonols by modified Algar–Flynn–Oyamada reaction and their antimicrobial activity. Chem Heterocycl Comp 52, 172–176 (2016). https://doi.org/10.1007/s10593-016-1852-4

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  • DOI: https://doi.org/10.1007/s10593-016-1852-4

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