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Synthesis and antiradical activity of 4-aryl(hetaryl)-substituted 3-aminopyridin-2(1Н)-ones

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of aryl(hetaryl)-substituted 1,3-diketones with chloroacetamide gave the respective N-(3-oxoalkenyl)chloroacetamides, which were converted to 3-pyridinium-substituted pyridin-2(1Н)-ones upon heating with excess of pyridine in n-butanol. The decomposition of pyridinium salts with hydrazine hydrate resulted in new 4-aryl(hetaryl)-substituted 3-aminopyridin-2(1Н)-ones, which showed strong antiradical activity with respect to ABTS and DPPH radicals.

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This study was performed with financial support from the Russian Foundation for Basic Research (project 15-53-45084 IND_a).

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Authors and Affiliations

  1. Department of Organic Chemistry, F. M. Dostoevskii Omsk State University, 55a Mira Ave., Omsk, 644077, Russia

    Ivan V. Kulakov, Mariya V. Matsukevich & Alexander S. Fisyuk

  2. Omsk State Technical University, 11 Mira Ave., Omsk, 644050, Russia

    Alexander S. Fisyuk

  3. RSE “ National Center for Biotechnology” of the Ministry of Education and Science, 13/5 Kurgalzhynskoe road, Astana, 010000, Kazakhstan

    Zarina T. Shulgau & Shyngys Sergazy

  4. Sh. Ualikhanov Kokshetau State University, 76 Abaya St., Kokshetau, 020000, Kazakhstan

    Tulegen M. Seilkhanov

  5. Department of Science & Humanities, National Institute of Technology Nagaland, Pin: 797 103, Dimapur, Nagaland, India

    Amrit Puzari

Authors
  1. Ivan V. Kulakov
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  2. Mariya V. Matsukevich
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  3. Zarina T. Shulgau
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  4. Shyngys Sergazy
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  5. Tulegen M. Seilkhanov
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  6. Amrit Puzari
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  7. Alexander S. Fisyuk
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Correspondence to Ivan V. Kulakov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(11/12), 991–996

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Kulakov, I.V., Matsukevich, M.V., Shulgau, Z.T. et al. Synthesis and antiradical activity of 4-aryl(hetaryl)-substituted 3-aminopyridin-2(1Н)-ones. Chem Heterocycl Comp 51, 991–996 (2015). https://doi.org/10.1007/s10593-016-1809-7

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  • DOI: https://doi.org/10.1007/s10593-016-1809-7

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