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Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities

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Chemistry of Heterocyclic Compounds Aims and scope

By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2Hchromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide had a good effect on lipase inhibition.

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Supporting material to this article, containing 1H and 13C NMR spectra and mass spectra of the obtained compounds, is available for authorized users.

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Correspondence to Emre Menteşe.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(5), 447–456

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Kahveci, B., Yılmaz, F., Menteşe, E. et al. Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities. Chem Heterocycl Comp 51, 447–456 (2015). https://doi.org/10.1007/s10593-015-1714-5

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