Novel 1-R-3,4-dihydro-5H-benzothieno[2,3-d][1,2]diazepin-4-ones have been prepared by the cyclization of 2-acyl(aroyl)benzo[b]thiophene-3-acetic acids or 1-R-benzothieno[2,3-c]pyr-3-ones with hydrazine hydrate.
Similar content being viewed by others
References
G. De Sarro, A. Chimirri, and B. S. Meldrum, Eur. J. Pharmacol., 451, 55 (2002).
A. De Sarro, G. De Sarro, R. Gitto, S. Grasso, N. Micale, and M. Zappalà, Farmaco, 54, 178 (1999).
R. Gitto, M. Zappalà, G. De Sarro, and A. Chimirri, Farmaco, 57, 129 (2002).
S. Quartarone, R. Caruso, V. Orlando, E. Russo, G. De Sarro, and A. Chimirri, Farmaco, 59, 353 (2004).
A. Chimirri, R. Gitto, S. Quartarone, V. Orlando, A. De Sarro, and G. B. De Sarro, Farmaco, 57, 759 (2002).
A. Chimirri, G. De Sarro, A. De Sarro, R. Gitto, S. Quartarone, M. Zappalà, A. Constanti, and V. Libri, J. Med. Chem., 41, 3409 (1998).
M. Zappalà, R. Gitto, F. Bevacqua, S. Quartarone, A. Chimirri, M. Rizzo, G. De Sarro, and A. De Sarro, J. Med. Chem., 43, 4834 (2000).
A. Chimirri, F. Bevacqua, R. Gitto, S. Quartarone, M. Zappalà, A. De Sarro, L. Maciocco, G. Biggio, and G. De Sarro, Med. Chem. Res., 9, 203 (1999).
A. Chimirri, M. Zappalà, R. Gitto, S. Quartarone, and F. Bevacqua, Heterocycles, 51, 1303 (1999).
F. Gatta, D. Piazza, M. R. Del Giudice, and M. Massotti, Farmaco, 40, 942 (1985).
F. Bevacqua, A. Basso, R. Gitto, M. Bradley, and A. Chimirri, Tetrahedron Lett., 42, 7683 (2001).
A. Monge, J. A. Palop, T. Goñí, A. Martínez, and E. Fernández-Alvarez, J. Heterocycl. Chem., 22, 1445 (1985).
V. S. Tolkunov, A. B. Eres'ko, A. I. Khizhan, O. V. Shishkin, G. V. Palamarchuk, and S. V. Tolkunov, Khim. Geterotsikl. Soedin., 907 (2009). [Chem. Heterocycl. Compd., 45, 726 (2009)].
A. B. Eres'ko, V. S. Tolkunov, and S. V. Tolkunov, Khim. Geterotsikl. Soedin., 1397 (2010). [Chem. Heterocycl. Compd., 46, 1127 (2010)].
V. S. Tolkunov, I. F. Perepichka, and V. I. Dulenko, J. Heterocycl. Chem., 42, 811 (2005).
V. S. Tolkunov, Yu. B. Vysotskii, O. A. Gorban', S. V. Shishkina, O. V. Shishkin, R. I. Zubatyuk, and V. I. Dulenko, Khim. Geterotsikl. Soedin., 601 (2005). [Chem. Heterocycl. Compd., 41, 515 (2005)].
S. V. Tolkunov, M. N. Kal'nitskii, and E. A. Zemskaya, Khim. Geterotsikl. Soedin., 1552 (1991). [Chem. Heterocycl. Compd., 27, 1253 (1991)].
G. N. Dorofeenko, S. V. Krivun, and E. I. Sadekova, Khim. Geterotsikl. Soedin., 730 (1971). [Chem. Heterocycl. Compd., 7, 681 (1971)].
H. Plieninger, W. Müller, and K. Weinert, Chem. Ber., 97, 667 (1964).
G. M. Sheldrick, Acta Crystallogr., Sect. A: Found, Crystallogr., A64, 112 (2008).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1471-1482, September, 2012.
Rights and permissions
About this article
Cite this article
Tolkunov, V.S., Eres᾽ko, A.B., Mazepa, A.V. et al. Condensed Diazepines. Synthesis of 1-R-3,4-Dihydro-5H-Benzothieno[2,3-d][1,2]Diazepin-4-Ones. Chem Heterocycl Comp 48, 1371–1381 (2012). https://doi.org/10.1007/s10593-012-1146-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10593-012-1146-4