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Condensed Diazepines. Synthesis of 1-R-3,4-Dihydro-5H-Benzothieno[2,3-d][1,2]Diazepin-4-Ones

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Chemistry of Heterocyclic Compounds Aims and scope

Novel 1-R-3,4-dihydro-5H-benzothieno[2,3-d][1,2]diazepin-4-ones have been prepared by the cyclization of 2-acyl(aroyl)benzo[b]thiophene-3-acetic acids or 1-R-benzothieno[2,3-c]pyr-3-ones with hydrazine hydrate.

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References

  1. G. De Sarro, A. Chimirri, and B. S. Meldrum, Eur. J. Pharmacol., 451, 55 (2002).

    Article  Google Scholar 

  2. A. De Sarro, G. De Sarro, R. Gitto, S. Grasso, N. Micale, and M. Zappalà, Farmaco, 54, 178 (1999).

    Article  Google Scholar 

  3. R. Gitto, M. Zappalà, G. De Sarro, and A. Chimirri, Farmaco, 57, 129 (2002).

    Article  CAS  Google Scholar 

  4. S. Quartarone, R. Caruso, V. Orlando, E. Russo, G. De Sarro, and A. Chimirri, Farmaco, 59, 353 (2004).

    Article  CAS  Google Scholar 

  5. A. Chimirri, R. Gitto, S. Quartarone, V. Orlando, A. De Sarro, and G. B. De Sarro, Farmaco, 57, 759 (2002).

    Article  CAS  Google Scholar 

  6. A. Chimirri, G. De Sarro, A. De Sarro, R. Gitto, S. Quartarone, M. Zappalà, A. Constanti, and V. Libri, J. Med. Chem., 41, 3409 (1998).

    Article  CAS  Google Scholar 

  7. M. Zappalà, R. Gitto, F. Bevacqua, S. Quartarone, A. Chimirri, M. Rizzo, G. De Sarro, and A. De Sarro, J. Med. Chem., 43, 4834 (2000).

    Article  Google Scholar 

  8. A. Chimirri, F. Bevacqua, R. Gitto, S. Quartarone, M. Zappalà, A. De Sarro, L. Maciocco, G. Biggio, and G. De Sarro, Med. Chem. Res., 9, 203 (1999).

    CAS  Google Scholar 

  9. A. Chimirri, M. Zappalà, R. Gitto, S. Quartarone, and F. Bevacqua, Heterocycles, 51, 1303 (1999).

    Article  CAS  Google Scholar 

  10. F. Gatta, D. Piazza, M. R. Del Giudice, and M. Massotti, Farmaco, 40, 942 (1985).

    CAS  Google Scholar 

  11. F. Bevacqua, A. Basso, R. Gitto, M. Bradley, and A. Chimirri, Tetrahedron Lett., 42, 7683 (2001).

    Article  CAS  Google Scholar 

  12. A. Monge, J. A. Palop, T. Goñí, A. Martínez, and E. Fernández-Alvarez, J. Heterocycl. Chem., 22, 1445 (1985).

    Article  CAS  Google Scholar 

  13. V. S. Tolkunov, A. B. Eres'ko, A. I. Khizhan, O. V. Shishkin, G. V. Palamarchuk, and S. V. Tolkunov, Khim. Geterotsikl. Soedin., 907 (2009). [Chem. Heterocycl. Compd., 45, 726 (2009)].

    Google Scholar 

  14. A. B. Eres'ko, V. S. Tolkunov, and S. V. Tolkunov, Khim. Geterotsikl. Soedin., 1397 (2010). [Chem. Heterocycl. Compd., 46, 1127 (2010)].

    Google Scholar 

  15. V. S. Tolkunov, I. F. Perepichka, and V. I. Dulenko, J. Heterocycl. Chem., 42, 811 (2005).

    Article  CAS  Google Scholar 

  16. V. S. Tolkunov, Yu. B. Vysotskii, O. A. Gorban', S. V. Shishkina, O. V. Shishkin, R. I. Zubatyuk, and V. I. Dulenko, Khim. Geterotsikl. Soedin., 601 (2005). [Chem. Heterocycl. Compd., 41, 515 (2005)].

    Google Scholar 

  17. S. V. Tolkunov, M. N. Kal'nitskii, and E. A. Zemskaya, Khim. Geterotsikl. Soedin., 1552 (1991). [Chem. Heterocycl. Compd., 27, 1253 (1991)].

    Google Scholar 

  18. G. N. Dorofeenko, S. V. Krivun, and E. I. Sadekova, Khim. Geterotsikl. Soedin., 730 (1971). [Chem. Heterocycl. Compd., 7, 681 (1971)].

    Google Scholar 

  19. H. Plieninger, W. Müller, and K. Weinert, Chem. Ber., 97, 667 (1964).

    Article  CAS  Google Scholar 

  20. G. M. Sheldrick, Acta Crystallogr., Sect. A: Found, Crystallogr., A64, 112 (2008).

    Article  CAS  Google Scholar 

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Correspondence to V. S. Tolkunov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1471-1482, September, 2012.

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Tolkunov, V.S., Eres᾽ko, A.B., Mazepa, A.V. et al. Condensed Diazepines. Synthesis of 1-R-3,4-Dihydro-5H-Benzothieno[2,3-d][1,2]Diazepin-4-Ones. Chem Heterocycl Comp 48, 1371–1381 (2012). https://doi.org/10.1007/s10593-012-1146-4

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  • DOI: https://doi.org/10.1007/s10593-012-1146-4

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