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Synthesis of alkyl hexahydropyrazino-[1,2-c]pyrimidine-9-carboxylates

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Chemistry of Heterocyclic Compounds Aims and scope

Cyclocondensation of 3-alkoxycarbonylmethylidenepiperazin-2-ones with α-chlorobenzyl isocyanates gave alkyl 8-aryl-1,6-dioxo-1,3,4,6,7,8-hexahydro-2H-pyrazino[1,2-c]pyrimidine-9-carboxylates. The use of 1-aryl-2,2,2-trifluoroethyl isocyanates in an analogous cyclization gave 6-aryl-1,8-dioxo-6-trifluoromethyl-1,3,4,6,7,8-hexahydro-2H-pyrazino[1,2-c]pyrimidine-9-carboxylates.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine

    M. V. Vovk, N. V. Melˈnichenko & I. F. Tsymbal

  2. Yu. Fedkovich Chernivtsi National University, 2 Kotsyubinsky St., Chernivtsi, 58012, Ukraine

    O. V. Kushnir

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  1. M. V. Vovk
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  2. O. V. Kushnir
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  3. N. V. Melˈnichenko
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  4. I. F. Tsymbal
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Correspondence to M. V. Vovk.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1205–1211, August, 2011.

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Vovk, M.V., Kushnir, O.V., Melˈnichenko, N.V. et al. Synthesis of alkyl hexahydropyrazino-[1,2-c]pyrimidine-9-carboxylates. Chem Heterocycl Comp 47, 989–995 (2011). https://doi.org/10.1007/s10593-011-0865-2

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  • DOI: https://doi.org/10.1007/s10593-011-0865-2

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