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A convenient synthesis and structural analysis of novel 4,5,6,7-tetrahydro-1H-indazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A new series of t-4-aryl-3,c-6-dihydroxy-6-methyl-4,5,6,7-tetrahydro-1H-indazole-r-5-carboxylic acid isopropyl esters has been synthesized by adopting a conventional method from cyclic β-keto esters. 1H, 13C NMR, and IR spectra for all the compounds were investigated. HMBC, HSQC, COSY, and NOESY spectra of the representative compounds were studied. The stereochemistry of a six-membered ring of the fused indazoles resembled that of keto esters. From the HMBC correlations the indazole structure was confirmed as 1H-indazole.

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Correspondence to R. T. Sabapathy Mohan.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 386-391, March, 2010.

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Murugavel, K., Amirthaganesan, S. & Sabapathy Mohan, R.T. A convenient synthesis and structural analysis of novel 4,5,6,7-tetrahydro-1H-indazoles. Chem Heterocycl Comp 46, 302–306 (2010). https://doi.org/10.1007/s10593-010-0505-2

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