Abstract
Adults with panic disorder (PD) often present to medical settings with noncardiac chest pain (NCCP), but less is known about children and adolescents with this complaint. We sought to characterize PD in youth with NCCP and compare features with PD in youth in psychiatric outpatient settings. Using a semi-structured diagnostic interview we evaluated 132 youth (ages 8–17) with NCCP recruited from two medical settings. Twenty-seven (20.5 %) met full DSM-IV criteria for PD, eleven of which were children (<13 years). Most frequent panic symptoms were somatic complaints, although cognitive symptoms were also common. Only 14.8 % had clinically significant agoraphobia. Comorbid anxiety disorders and major depression were common. Overall, clinical features of PD among youth with NCCP are similar to PD in psychiatric settings. Interventions for PD may benefit youth who present initially with NCCP. Systematic psychiatric screening could increase detection of PD and improve care for this population.
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Hershberg SG, Carlson GA, Cantwell DP, Strober M (1982) Anxiety and depressive disorders in psychiatrically disturbed children. J Clin Psychiatry 43:358–361
Nelles WB, Barlow DH (1988) Do children panic? Clin Psychol Rev 8:359–372
Thyer BA, Parrish RT, Curtis GC, Nesse RM, Cameron OG (1985) Ages of onset of DSM-III anxiety disorders. Compr Psychiatry 26:113–122
von Korff MR, Eaton WW, Keyl PM (1985) The epidemiology of panic attacks and panic disorder. Results of three community surveys. Am J Epidemiol 122:970–981
Essau CA, Conradt J, Petermann F (1999) Frequency of panic attacks and panic disorder in adolescents. Depress Anxiety 9:19–26
Hayward C, Killen JD, Kraemer HC, Taylor C (2000) Predictors of panic attacks in adolescents. Am Acad Child Adolesc Psychiatry 39:207–214
Hayward C, Killen JD, Kraemer HC, Blair-Greiner A, Strachowski D, Cunning D, Taylor CB (1997) Assessment and phenomenology of nonclinical panic attacks in adolescent girls. J Anxiety Disord 11:17–32
Macaulay JL, Kleinknecht RA (1989) Panic and panic attacks in adolescents. J Anxiety Disord 3:221–241
Merikangas KR, He JP, Burstein M, Swendsen J, Avenevoli S, Case B et al (2011) Service utilization for lifetime mental disorders in U.S. adolescents: results of the National Comorbidity Survey-Adolescent Supplement (NCS-A). J Am Acad Child Adolesc Psychiatry 50:32–45
Merikangas KR, He JP, Brody D, Fisher PW, Bourdon K, Koretz DS (2010) Prevalence and treatment of mental disorders among US children in the 2001–2004 NHANES. Pediatrics 125:75–81
Alessi NE, Magen J (1988) Panic disorder in psychiatrically hospitalized children. Am J Psychiatry 145:1450–1452
Ballenger JC, Carek DJ, Steele JJ, Cornish-McTighe D (1989) Three cases of panic disorder with agoraphobia in children. Am J Psychiatry 146:922–924
Last CG, Strauss CC (1989) Panic disorder in children and adolescents. J Anxiety Disord 3:87–95
Kearney CA, Albano AM, Eisen AR, Allan WD, Barlow DH (1997) The phenomenology of panic disorder in youngsters: an empirical study of a clinical sample. J Anxiety Disord 11:49–62
Diler RS, Birmaher B, Brent DA, Axelson DA, Firinciogullari S, Chiapetta L et al (2004) Phenomenology of panic disorder in youth. Depress Anxiety 20:39–43
Biederman J, Faraone SV, Marrs A, Moore P, Garcia J, Ablon JS et al (1997) Panic disorder and agoraphobia in consecutively referred children and adolescents. J Am Acad Child Adolesc Psychiatry 36:214–223
Masi G, Favilla L, Mucci M, Millepiedi S (2000) Panic disorder in clinically referred children and adolescents. Child Psychiatry Hum Dev 31:139–151
Doerfler LA, Connor DF, Volungis AM, Toscano PF (2007) Panic disorder in clinically referred children and adolescents. Child Psychiatry Hum Dev 38:57–71
Fleet RP, Marchand A, Dupuis G, Kaczorowski J, Beitman BD (1998) Comparing emergency department and psychiatric setting patients with panic disorder. Psychosomatics 39:512–518
Oral E, Aydin N, Gulec M, Oral M (2012) Panic disorder and subthreshold panic in the light of comorbidity: a follow-up study. Compr Psychiatry 53:988–994
Weissman MM, Klerman GL, Markowitz JS, Ouellette R (1989) Suicidal ideation and suicide attempts in panic disorder and attacks. N Engl J Med 321:1209–1214
Ramsawh HJ, Weisberg RB, Dyck I, Stout R, Keller MB (2011) Age of onset, clinical characteristics, and 15-year course of anxiety disorders in a prospective, longitudinal, observational study. J Affect Disord 132:260–264
Garland EJ, Smith DH (1990) Panic disorder on a child psychiatric consultation service. J Am Acad Child Adolesc Psychiatry 29:785–788
Moreau D, Weissman MM (1992) Panic disorder in children and adolescents: a review. Am J Psychiatry 149:1306–1314
Ollendick TH (1995) Cognitive behavioral treatment of panic disorder with agoraphobia in adolescents: a multiple baseline design analysis. Behav Ther 26:517–531
Herskowitz J (1986) Neurologic presentations of panic disorder in childhood and adolescence. Dev Med Child Neurol 28:617–623
Van Winter JT, Stickler GB (1984) Panic attack syndrome. J Pediatr 105:661–665
Herman SP, Stickler GB, Lucas AR (1981) Hyperventilation syndrome in children and adolescents: long-term follow-up. Pediatrics 67:183–187
Beitman BD, Mukerji V, Lamberti JW, Schmid L, DeRosear L, Kushner M et al (1989) Panic disorder in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol 63:1399–1403
Katon WJ (1990) Chest pain, cardiac disease, and panic disorder. J Clin Psychiatry 51:27–30
Fleet RP, Dupuis G, Marchand A, Burelle D, Arsenault A, Beitman BD (1996) Panic disorder in emergency department chest pain patients: prevalence, comorbidity, suicidal ideation, and physician recognition. Am J Med 101:371–380
Garber J, Walker LS, Zeman J (1991) Somatization symptoms in a community sample of children and adolescents: further validation of the Children’s Somatization Inventory. Psychol Assess 3:588–595
National Center for Health Statistics (1998) National Ambulatory Medical Care Survey
Selbst SM, Ruddy RM, Clark BJ, Henretig FM, Santulli T Jr (1988) Pediatric chest pain: a prospective study. Pediatrics 82:319–323
Brenner JI, Ringel RE, Berman MA (1984) Cardiologic perspectives of chest pain in childhood: a referral problem? To whom? Pediatr Clin North Am 31:1241–1258
Drossner DM, Hirsh DA, Sturm JJ, Mahle WT, Goo DJ, Massey R et al (2011) Cardiac disease in pediatric patients presenting to a pediatric ED with chest pain. Am J Emerg Med 29:632–638
Friedman KG, Kane DA, Rathod RH, Renaud A, Farias M, Geggel R et al (2011) Management of pediatric chest pain using a standardized assessment and management plan. Pediatrics 128:239–245
Brown RT (1981) Costochondritis in adolescents. J Adolesc Health Care 1:198–201
Kocis KC (1999) Chest pain in pediatrics. Pediatr Clin North Am 46:189–203
Sharkey AM, Clark BJ (1991) Common complaints with cardiac implications in children. Pediatr Clin North Am 38:657–666
Selbst SM, Ruddy R, Clark BJ (1990) Chest pain in children. Follow-up of patients previously reported. Clin Pediatr 29:374–377
Lipsitz JD, Gur M, Sonnet FM, Dayan PS, Miller SZ, Brown C et al (2010) Psychopathology and disability in children with unexplained chest pain presenting to the pediatric emergency department. Pediatr Emerg Care 26:830–836
Lipsitz JD, Masia C, Apfel H, Marans Z, Gur M, Dent H et al (2005) Noncardiac chest pain and psychopathology in children and adolescents. J Psychosom Res 59:185–188
Lipsitz JD, Hsu DT, Apfel HD, Marans ZS, Cooper RS, Albano AM et al (2012) Psychiatric disorders in youth with medically unexplained chest pain versus innocent heart murmur. J Pediatr 160:320–324
Silverman WK, Albano AM, Corporation P (1996) Anxiety disorders interview schedule for DSM-IV: child version. Oxford University Press, Oxford
Silverman WK, Saavedra LM, Pina AA (2001) Test–retest reliability of anxiety symptoms and diagnoses with the anxiety disorders interview schedule for DSM-IV: child and parent versions. J Am Acad Child Adolesc Psychiatry 40:937–944
Wood JJ, Piacentini JC, Bergman RL, McCracken J, Barrios V (2002) Concurrent validity of the anxiety disorders section of the anxiety disorders interview schedule for DSM-IV: child and parent versions. J Clin Child Adolesc Psychol 31:335–342
McDonnell CJ, White KS, Grady RM (2012) Noncardiac chest pain in children and adolescents: a biopsychosocial conceptualization. Child Psychiatry Hum Dev 43:1–26
Lipsitz JD, Gur M, Albano AM, Sherman B (2011) A psychological intervention for pediatric chest pain: development and open trial. J Dev Behav Pediatr 32:153–157
Szatmari P, Offord DR, Boyle MH (1989) Ontario Child Health Study: prevalence of attention deficit disorder with hyperactivity. J Child Psychol Psychiatry 30:219–223
McMILLER WP, Weisz JR (1996) Help-seeking preceding mental health clinic intake among African-American, Latino, and Caucasian youths. J Am Acad Child Adolesc Psychiatry 35:1086–1094
Barrera TL, Wilson KP, Norton PJ (2010) The experience of panic symptoms across racial groups in a student sample. J Anxiety Disord 24:873–878
Battaglia M, Bertella S, Politi E, Bernardeschi L (1995) Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. Am J Psychiatry 152:1362–136454
Masi G, Pari C, Millepiedi S (2006) Pharmacological treatment options for panic disorder in children and adolescents. Expert Opin Pharmacother 7:545–554
Berle D, Starcevic V, Milicevic D, Hannan A, Moses K (2010) Do symptom interpretations mediate the relationship between panic attack symptoms and agoraphobic avoidance? Behav Cogn Psychother 38:275–289
Pantell RH, Goodman BW Jr (1983) Adolescent chest pain: a prospective study. Pediatrics 71:881–887
Reed V, Wittchen HU (1998) DSM-IV panic attacks and panic disorder in a community sample of adolescents and young adults: how specific are panic attacks? J Psychiatr Res 32:335–345
Kessler RC, Zhao S, Katz SJ, Kouzis AC, Frank RG, Edlund M et al (1999) Past-year use of outpatient services for psychiatric problems in the National Comorbidity Survey. Am J Psychiatry 156:115–123
Pincus DB, May JE, Whitton SW, Mattis SG, Barlow DH (2010) Cognitive-behavioral treatment of panic disorder in adolescence. J Clin Child Adolesc Psychol 39:638–649
Lessard MJ, Marchand A, Pelland MÈ, Belleville G, Vadeboncoeur A, Chauny JM et al (2011) Comparing two brief psychological interventions to usual care in panic disorder patients presenting to the emergency department with chest pain. Behav Cogn Psychother 1:1–19
Wang SJ, Juang KD, Fuh JL, Lu SR (2007) Psychiatric comorbidity and suicide risk in adolescents with chronic daily headache. Neurology 68:1468–1473
Barsky AJ, Cleary PD, Coeytaux RR, Ruskin JN (1994) Psychiatric disorders in medical outpatients complaining of palpitations. J Gen Intern Med 9:306–313
Ramsawh HJ, Chavira DA, Stein MB (2010) Burden of anxiety disorders in pediatric medical settings: prevalence, phenomenology, and a research agenda. Arch Pediatr Adolesc Med 164:965–972
Mayou RA, Bryant BM, Sanders D, Bass C, Klimes I, Forfar C (1997) A controlled trial of cognitive behavioural therapy for non-cardiac chest pain. Psychol Med 27:1021–1031
Puig-Antich J, Chambers W (1978) Schedule for affective disorders and schizophrenia for school-age children (KIDDIE-SADS). New York State Psychiatric Institute, New York
Chambers WJ, Puig-Antich J, Hirsch M, Paez P, Ambrosini PJ, Tabrizi MA et al (1985) The assessment of affective disorders in children and adolescents by semistructured interview. Test–retest reliability of the schedule for affective disorders and schizophrenia for school-age children, present episode version. Arch Gen Psychiatry 42:696–702
Orvaschel H, Puig-Antich J (1987) Schedule for affective disorders and schizophrenia for school-age children: epidemiologic version: Kiddie SADSE-E (K-SADSE-E), 4th edn. Western Psychiatric Institute and Clinic, Pittsburgh, PA
Reich W, Shayka JJ, Taibleson C (1991) Diagnostic interview for children and adolescents (DICA-R). Unpublished manuscript, Division of Child Psychiatry, Washington University, St. Louis
Orvaschel H (1995) Schedule for affective disorders and schizophrenia for school-aged children. Epidiologic version—5. Center for Psychological Studies, Nova Southeastern University, Fort Lauderdale, FL
Acknowledgments
Supported by National Institute of Mental Health (grants R01-MH067912 and K08-MH01575 to J.L). We would like to thank Ann Marie Albano, PhD for her assistance with training on the ADIS: C/P.
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Achiam-Montal, M., Tibi, L. & Lipsitz, J.D. Panic Disorder in Children and Adolescents with Noncardiac Chest Pain. Child Psychiatry Hum Dev 44, 742–750 (2013). https://doi.org/10.1007/s10578-013-0367-9
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DOI: https://doi.org/10.1007/s10578-013-0367-9