Article

Chromosome Research

, Volume 21, Issue 2, pp 101-106

Open Access This content is freely available online to anyone, anywhere at any time.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

  • W. C. EarnshawAffiliated withWellcome Trust Centre for Cell Biology, University of Edinburgh Email author 
  • , R. C. AllshireAffiliated withWellcome Trust Centre for Cell Biology, University of Edinburgh
  • , B. E. BlackAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
  • , K. BloomAffiliated withDepartment of Biology, University of North Carolina at Chapel Hill
  • , B. R. BrinkleyAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of Medicine
  • , W. BrownAffiliated withSchool of Biology, Medical School Queen’s Medical Centre, University of Nottingham
  • , I. M. CheesemanAffiliated withWhitehead Institute and Department of Biology, MIT
  • , K. H. A. ChooAffiliated withChromosome Research, Murdoch Childrens Research Institute, Department of Paediatrics, Royal Children’s Hospital
  • , G. P. CopenhaverAffiliated withDepartment of Biology and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill
    • , J. G. DeLucaAffiliated withDepartment of Biochemistry and Molecular Biology, Colorado State University
    • , A. DesaiAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghLudwig Institute for Cancer Research, University of California at San Diego
    • , S. DiekmannAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghMolecular Biology, FLI
    • , S. ErhardtAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghZMBH, DKFZ-ZMBH Alliance, University of Heidelberg
    • , M. Fitzgerald-HayesAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghDepartment of Biochemistry and Molecular Biology, University of Massachusetts
    • , D. FoltzAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghDepartment of Biochemistry and Molecular Genetics, University of Virginia
    • , T. FukagawaAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghDepartment of Molecular Genetics, National Institute of Genetics
    • , R. GassmannAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghIBMC—Instituto de Biologia Molecular e Celular, Universidade do Porto
    • , D. W. GerlichAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
    • , D. M. GloverAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghDepartment of Genetics, University of Cambridge
    • , G. J. GorbskyAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghCell Cycle and Cancer Biology, Oklahoma Medical Research Foundation
    • , S. C. HarrisonAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaJack and Eileen Connors Structural Biology Laboratory, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Howard Hughes Medical Institute
    • , P. HeunAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaMax Planck Institute of Immunobiology and Epigenetics
    • , T. HirotaAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaCancer Institute of the Japanese Foundation for Cancer Research (JFCR)
    • , L. E. T. JansenAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaInstituto Gulbenkian de Ciência
    • , G. KarpenAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaLawrence Berkeley National Lab, Life Sciences Division and UC Berkeley, Department of Molecular and Cell Biology
    • , G. J. P. L. KopsAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaDepartments of Medical Oncology and Cancer Genomics Netherlands, University Medical Center Utrecht
    • , M. A. LampsonAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biology, University of Pennsylvania
    • , S. M. LensAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaDepartment of Medical Oncology, University Medical Center Utrecht
    • , A. LosadaAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaChromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
    • , K. LugerAffiliated withDepartment of Biochemistry and Molecular Biology, Colorado State University
    • , H. MaiatoAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghIBMC—Instituto de Biologia Molecular e Celular, Universidade do Porto
    • , P. S. MaddoxAffiliated withDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaInstitute for Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal
    • , R. L. MargolisAffiliated withDepartment of Biology, University of North Carolina at Chapel HillTumor Development Program, Sanford-Burnham Medical Research Institute
    • , H. MasumotoAffiliated withDepartment of Biology, University of North Carolina at Chapel HillDepartment of Human Genome Research, Kazusa DNA Research Institute
    • , A. D. McAinshAffiliated withDepartment of Biology, University of North Carolina at Chapel HillCentre for Mechanochemical Cell Biology, Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick
    • , B. G. MelloneAffiliated withDepartment of Biology, University of North Carolina at Chapel HillDepartment of Molecular and Cell Biology, University of Connecticut
    • , P. MeraldiAffiliated withDepartment of Biology, University of North Carolina at Chapel HillPhysiology and Metabolism Department, Medical Faculty, University of Geneva
    • , A. MusacchioAffiliated withDepartment of Biology, University of North Carolina at Chapel HillDepartment of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
    • , K. OegemaAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghLudwig Institute for Cancer Research, University of California at San Diego
    • , R. J. O’NeillAffiliated withDepartment of Biology, University of North Carolina at Chapel HillDepartment of Molecular and Cell Biology, University of Connecticut
    • , E. D. SalmonAffiliated withDepartment of Biology, University of North Carolina at Chapel Hill
    • , K. C. ScottAffiliated withDepartment of Biology, University of North Carolina at Chapel HillInstitute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke University
    • , A. F. StraightAffiliated withDepartment of Biology, University of North Carolina at Chapel HillDepartment of Biochemistry, Stanford University
    • , P. T. StukenbergAffiliated withDepartment of Biology, University of North Carolina at Chapel HillDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
    • , B. A. SullivanAffiliated withDepartment of Biology, University of North Carolina at Chapel HillInstitute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke University
    • , K. F. SullivanAffiliated withDepartment of Biology, University of North Carolina at Chapel HillCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway
    • , C. E. SunkelAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineIBMC—Instituto de Biologia Molecular e Celular and ICBAS—Instituto de Ciencias Biomédica Abel Salazar, Universidade do Porto
    • , J. R. SwedlowAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineCentre for Gene Regulation and Expression, College of Life Sciences, University of Dundee
    • , C. E. WalczakAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineMedical Sciences Program, Indiana University
    • , P. E. WarburtonAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
    • , S. WestermannAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineResearch Institute of Molecular Pathology (IMP)
    • , H. F. WillardAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineInstitute for Genome Sciences and Policy, Duke University
    • , L. WordemanAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Physiology and Biophysics, University of Washington School of Medicine
    • , M. YanagidaAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineG0 Cell Unit, Okinawa Institute of Science and Technology Graduate University
    • , T. J. YenAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineFox Chase Cancer Center
    • , K. YodaAffiliated withDepartment of Molecular and Cellular Biology, Baylor College of MedicineBioscience and Biotechnology Center, Nagoya University
    • , D. W. ClevelandAffiliated withWellcome Trust Centre for Cell Biology, University of EdinburghLudwig Institute for Cancer Research, University of California at San Diego Email author 

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Keywords

centromere CENP-A histone kinetochore CenH3