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Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones

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Abstract

Chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be a high efficient heterogeneous catalyst to solve this problem. Under Zn–SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.

Graphical Abstract

Improving chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be efficient heterogeneous catalyst to solve this problem. Under Zn-SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.

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Acknowledgments

The authors are grateful to Tianjin Municipal Science and Technology Commission for its financial support.

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Authors and Affiliations

  1. Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300384, People’s Republic of China

    Li Jun Zhang, Xiang Zhang, Zhen Sheng You, Heng Li & Tian Feng

  2. General Section, Shuishanggongyuan Hospital, Tianjin, 300191, People’s Republic of China

    Wei Li Wang

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  1. Li Jun Zhang
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  2. Xiang Zhang
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  3. Zhen Sheng You
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  4. Heng Li
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  5. Tian Feng
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Correspondence to Li Jun Zhang.

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Zhang, L.J., Zhang, X., You, Z.S. et al. Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones. Catal Lett 146, 2081–2086 (2016). https://doi.org/10.1007/s10562-016-1806-6

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  • DOI: https://doi.org/10.1007/s10562-016-1806-6

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