Biotinylated Metathesis Catalysts: Synthesis and Performance in Ring Closing Metathesis
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- Kajetanowicz, A., Chatterjee, A., Reuter, R. et al. Catal Lett (2014) 144: 373. doi:10.1007/s10562-013-1179-z
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Nine biotinylated Grubbs–Hoveyda and Grubbs-type metathesis catalysts were synthesized and evaluated in ring closing metathesis reactions of N-tosyl diallylamine and 5-hydroxy-2-vinylphenyl acrylate. Their catalytic activity in organic- and aqueous solvents was compared with the second generation Grubbs–Hoveyda catalyst. The position of the biotin-moiety on the N-heterocyclic carbene was found to critically influence the catalytic activity of the corresponding ruthenium-based catalysts.