Catalysis Letters

, 141:882

Acetone Cyanohydrin: A Convenient Alternative of Toxic Sodium Cyanide/Acetic Acid for Oxidative Cyanation of Tertiary Amines


DOI: 10.1007/s10562-011-0582-6

Cite this article as:
Verma, S., Jain, S.L. & Sain, B. Catal Lett (2011) 141: 882. doi:10.1007/s10562-011-0582-6


Acetone cyanohydrin was found to be a facile, convenient and comparatively safer alternative to toxic sodium cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines to α-aminonitriles in high yields with hydrogen peroxide using RuCl3 as catalyst. In addition organic nature of acetone cyanohydrin makes it more suitable for an organic transformation since it is readily soluble in reaction medium and can be added in a controlled manner.

Graphical Abstract


Acetone cyanohydrinCyanationOxidationTertiary AmineRuthenium

Supplementary material

10562_2011_582_MOESM1_ESM.doc (30 kb)
Supplementary material 1 (DOC 30 kb)

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Chemical Sciences DivisionIndian Institute of Petroleum (Council of Scientific and Industrial Research)DehradunIndia