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KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis

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Abstract

KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility. However, recent studies suggest that KiSS1 and GPR54 have varied roles even in cancer development and metastasis. Here, we examine recent advances in understanding the roles of KiSS1 and GPR54 in cancer development and metastasis.

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Acknowledgment

This work was supported by National Cancer Institute/NIH grant 1R01CA106479 and grant from National Science Foundation of China (30930055).

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Authors and Affiliations

  1. Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA

    Sung-Gook Cho, Kunrong Tan, Stefan K. Siwko & Mingyao Liu

  2. The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China

    Dali Li & Mingyao Liu

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  1. Sung-Gook Cho
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Correspondence to Mingyao Liu.

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Cho, SG., Li, D., Tan, K. et al. KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis. Cancer Metastasis Rev 31, 585–591 (2012). https://doi.org/10.1007/s10555-012-9367-7

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