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Molecular characterization of circulating tumor cells in breast cancer: challenges and promises for individualized cancer treatment

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Abstract

Blood testing using Circulating Tumor Cells (CTCs) has emerged as one of the hottest fields in cancer diagnosis. Research on CTCs present nowadays a challenge, as these cells are well defined targets for understanding tumour biology and improving cancer treatment. The presence of tumor cells in patient’s bone marrow or peripheral blood is an early indicator of metastasis and may signal tumor spread sooner than clinical symptoms appear and imaging results confirm a poor prognosis. CTC enumeration can serve as a “liquid biopsy” and an early marker to assess response to systemic therapy. Definition of biomarkers based on comprehensive characterization of CTCs has a strong potential to be translated to individualized targeted treatments and spare breast cancer patients unnecessary and ineffective therapies but also to reduce the costs for the health system and to downsize the extent and length of clinical studies. In this review, we briefly summarize recent studies on the molecular characterization of circulating tumor cells in breast cancer and discuss challenges and promises of CTCs for individualized cancer treatment.

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Acknowledgments

The present work was funded by SYNERGASIA 2009 PROGRAMME. This program is co-funded by the European Regional Development Fund and National Resources (project code: ONCOSEED diagnostics).

Conflict of interest

No potential conflicts of interest were disclosed.

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  1. Analysis of Circulating Tumor Cells Lab, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, 15771, Athens, Greece

    Evi S. Lianidou, Athina Markou & Areti Strati

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  2. Athina Markou
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  3. Areti Strati
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Correspondence to Evi S. Lianidou.

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Lianidou, E.S., Markou, A. & Strati, A. Molecular characterization of circulating tumor cells in breast cancer: challenges and promises for individualized cancer treatment. Cancer Metastasis Rev 31, 663–671 (2012). https://doi.org/10.1007/s10555-012-9366-8

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  • DOI: https://doi.org/10.1007/s10555-012-9366-8

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