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Cyclooxygenase-2 and Gastric Cancer

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Abstract

Gastric cancer remains a leading cause of cancer-related deaths worldwide, although its incidence has been steadily declining during recent decades. Expression of cyclooxygenase-2 (COX-2) is elevated in gastric carcinomas and in their precursor lesions. COX-2 expression associates with reduced survival in gastric cancer patients, and it has also been shown to be an independent factor of poor prognosis. Several molecular mechanisms are involved in the regulation of COX-2 expression in gastric cancer cell lines, including signal transduction pathways activated by Helicobacter pylori. In gastric tumor models in vivo the role of COX-2 seems to be predominantly to facilitate tumor promotion and growth.

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Authors and Affiliations

  1. Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

    Alexandra Thiel, Johanna Mrena & Ari Ristimäki

  2. Genome-Scale Biology, Research Program Unit, University of Helsinki, Helsinki, Finland

    Alexandra Thiel & Ari Ristimäki

  3. Department of Gastrointestinal Surgery, Central Hospital of Central Finland, Jyväskylä, Finland

    Johanna Mrena

  4. Genome-Scale Biology, Research Program Unit, Biomedicum Helsinki, University of Helsinki, Room B529b, P.O. Box 63 (Haartmaninkatu 8), 00014, Helsinki, Finland

    Ari Ristimäki

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  1. Alexandra Thiel
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  2. Johanna Mrena
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  3. Ari Ristimäki
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Correspondence to Ari Ristimäki.

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Thiel, A., Mrena, J. & Ristimäki, A. Cyclooxygenase-2 and Gastric Cancer. Cancer Metastasis Rev 30, 387–395 (2011). https://doi.org/10.1007/s10555-011-9312-1

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