NON-THEMATIC REVIEW

Cancer and Metastasis Reviews

, Volume 29, Issue 4, pp 751-759

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

  • Carlos A. CastanedaAffiliated withInstituto Nacional Enfermedades Neoplásicas Email author 
  • , Hernán Cortes-FunesAffiliated withHospital Universitario 12 de Octubre
  • , Henry L. GomezAffiliated withInstituto Nacional Enfermedades Neoplásicas
  • , Eva M. CiruelosAffiliated withHospital Universitario 12 de Octubre

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Abstract

The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway mediates the effects of a variety of extracellular signals in a number of cellular processes including cell growth, proliferation, and survival. The alteration of integrants of this pathway through mutation of its coding genes increases the activation status of the signaling and can thus lead to cellular transformation. The frequent dysregulation of the PI3K/Akt pathway in breast cancer (BC) and the mediation of this pathway in different processes characteristically implicated in tumorigenesis have attracted the interest of this pathway in BC; however, a more comprehensive understanding of the signaling intricacies is necessary to develop clinical applications of the modulation of this pathway in this pathology. We review a series of experiments examining the contribution of alteration of integrants of this signaling network to human BC and we make an update of the information about the effect of the modulation of this pathway in this cancer.

Keywords

PIK3CA PTEN p110α Akt mTOR breast cancer