Article

Cancer and Metastasis Reviews

, Volume 28, Issue 1, pp 77-83

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

  • T. Y. KimAffiliated withDepartment of Pharmacology, University of North Carolina School of MedicineLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine
  • , D. VigilAffiliated withDepartment of Pharmacology, University of North Carolina School of MedicineLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine
  • , C. J. DerAffiliated withDepartment of Pharmacology, University of North Carolina School of MedicineLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine
  • , R. L. JulianoAffiliated withDepartment of Pharmacology, University of North Carolina School of MedicineLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine Email author 

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Abstract

DLC-1 was originally identified as a potential tumor suppressor. One of the key biochemical functions of DLC-1 is to serve as a GTPase activating protein (GAP) for members of the Rho family of GTPases, particularly Rho A-C and Cdc 42. Since these GTPases are critically involved in regulation of the cytoskeleton and cell migration, it seems clear that DLC-1 will also influence these processes. In this review we examine basic aspects of the actin cyoskeleton and how it relates to cell motility. We then delineate the characteristics of DLC-1 and other members of its family, and describe how they may have multiple effects on the regulation of cell polarity, actin organization, and cell migration.

Keywords

DLC-1 Cell migration Cell invasion