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Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis

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Abstract

Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle tracking strain analysis in patients with DM1. Aortic PWV was assessed with cardiovascular magnetic resonance in 41 DM1 patients. Patients underwent echocardiography for assessment of conventional LV diastolic function indices and LV and LA longitudinal strain and strain rate (SR) assessed with speckle tracking strain analysis. LV SR during the isovolumic relaxation period (SRIVR) and LA strain were recorded and the E-wave velocity to SRIVR velocity ratio (E/SRIVR) was calculated. Independent samples t test and multivariate linear regression analyses were used for statistical analyses. Aortic PWV significantly correlated with SRIVR (β = −0.71, p < 0.001), E/SRIVR (β = 0.61, p = 0.002) and LA strain (β = −0.47, p = 0.014), but not with conventional echocardiographic markers of diastolic function (all p > 0.10). In DM1 patients, aortic stiffness is inversely associated with sensitive markers of LV diastolic function and decrease in LA compliance as measured with echocardiographic speckle tracking strain analysis.

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Acknowledgments

Foundation by the Netherlands Heart Foundation (Project UL 2009-4548) is gratefully acknowledged. Dr. Jos J.M. Westenberg is supported by an unconditional grant provided by Dr. Rainer Bluemm (Essen, Germany).

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Authors and Affiliations

  1. Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, C4-67, 2333 ZA, Leiden, The Netherlands

    Linda D. van Schinkel & Johannes W. A. Smit

  2. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

    Dominique Auger, Nina Ajmone Marsan, Victoria Delgado, Arnold C. T. Ng & Jeroen J. Bax

  3. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

    Saskia G. C. van Elderen, Hildo J. Lamb, Jos J. M. Westenberg & Albert de Roos

Authors
  1. Linda D. van Schinkel
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  2. Dominique Auger
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  3. Saskia G. C. van Elderen
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  4. Nina Ajmone Marsan
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  5. Victoria Delgado
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  6. Hildo J. Lamb
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  7. Arnold C. T. Ng
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  8. Johannes W. A. Smit
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  9. Jeroen J. Bax
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  10. Jos J. M. Westenberg
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  11. Albert de Roos
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Correspondence to Linda D. van Schinkel.

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van Schinkel, L.D., Auger, D., van Elderen, S.G.C. et al. Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. Int J Cardiovasc Imaging 29, 633–641 (2013). https://doi.org/10.1007/s10554-012-0125-2

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  • DOI: https://doi.org/10.1007/s10554-012-0125-2

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