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Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer

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Abstract

Background

Heterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported.

Methods

Four previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking.

Results

While some quantitative variation was evident, distinct molecular subtype schemes showed considerable consistency in the association with the risk factors. Generally, compared to patients with luminal-like tumors, patients with basal-like subtypes were more likely to be older (OR75 + yrs vs. <60 years range = 1.32–2.89), obese (ORobese vs. normal range = 1.30–3.05), and to start smoking at early age (OR<18 years vs. 25+ years range = 1.11–4.57).

Conclusions

Different molecular subtypes of MIBC may have distinct risk profiles. Large population-based studies with detailed information on bladder cancer risk factors are needed to further define etiologic heterogeneity for bladder cancer.

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Acknowledgments

This project was supported by the University Cancer Research Fund from the University of North Carolina at Chapel Hill.

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Authors and Affiliations

  1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Suite 32, CVS Plaza, 137 East Franklin Street, CB#8050, Chapel Hill, NC, 27599, USA

    Xuezheng Sun, Andrew F. Olshan & Melissa A. Troester

  2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Katherine A. Hoadley, William Y. Kim, Andrew F. Olshan & Melissa A. Troester

  3. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Katherine A. Hoadley & William Y. Kim

  4. Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    William Y. Kim

  5. Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    William Y. Kim

  6. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Helena Furberg

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  1. Xuezheng Sun
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  2. Katherine A. Hoadley
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  3. William Y. Kim
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  4. Helena Furberg
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Corresponding author

Correspondence to Xuezheng Sun.

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None declared.

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Sun, X., Hoadley, K.A., Kim, W.Y. et al. Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer. Cancer Causes Control 28, 539–544 (2017). https://doi.org/10.1007/s10552-017-0885-z

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  • DOI: https://doi.org/10.1007/s10552-017-0885-z

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