Original paper

Cancer Causes & Control

, Volume 24, Issue 4, pp 783-793

Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms

  • Audrey BonaventureAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupUniv Paris-Sud, UMRS 1018
  • , Jérémie RudantAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupUniv Paris-Sud, UMRS 1018RNHE, National Registry of Childhood Hematopoietic Malignancies Email author 
  • , Stéphanie Goujon-BellecAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupUniv Paris-Sud, UMRS 1018RNHE, National Registry of Childhood Hematopoietic Malignancies
  • , Laurent OrsiAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupUniv Paris-Sud, UMRS 1018
  • , Guy LevergerAffiliated withAP-HP, Hôpital Armand TrousseauUniversité Paris 6 Pierre et Marie Curie
  • , André BaruchelAffiliated withAP-HP, Hôpital Robert DebréUniversité Paris 7
  • , Yves BertrandAffiliated withInstitut d’Hémato-Oncologie Pédiatrique
  • , Brigitte NelkenAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupHôpital Jeanne de Flandre, CHRUUniversité Lille Nord de France
  • , Marlène PasquetAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupHôpital des Enfants
    • , Gérard MichelAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupAP-HM, Hôpital la Timone
    • , Nicolas SirventAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupHôpital Arnaud de Villeneuve
    • , Pierre BordigoniAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupCHU de Nancy
    • , Stéphane DucassouAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupHematology and Oncology, Children’s Hospital, Pellegrin, Bordeaux University Hospital
    • , Xavier RiallandAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupHôpital Mère-Enfant, CHU-NantesCHU d’Angers
    • , Diana ZelenikaAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupCommissariat à l’Energie Atomique (CEA) Genomics Institute-Centre National de Génotypage
    • , Denis HémonAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupUniv Paris-Sud, UMRS 1018
    • , Jacqueline ClavelAffiliated withInserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer GroupUniv Paris-Sud, UMRS 1018RNHE, National Registry of Childhood Hematopoietic Malignancies

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Abstract

Purpose

This study aimed to analyze the associations between childhood acute leukemia (AL) and maternal caffeinated beverage consumption during pregnancy, and to explore interactions between caffeinated and alcoholic beverage consumption and polymorphisms of enzymes involved in caffeine and ethanol metabolisms.

Methods

The data were generated by the French ESCALE study, which included 764 AL cases and 1,681 controls in 2003–2004. The case and control mothers were interviewed on their consumption habits during pregnancy using a standardized questionnaire. Genotypes of the candidate alleles (NAT2*5 rs1801280, ADH1C*2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867) were obtained using high-throughput genotyping and imputation data for 493 AL cases and 549 controls with at least two grandparents born in Europe.

Results

Maternal regular coffee consumption during pregnancy was associated with childhood AL (OR = 1.2 [1.0–1.5], p = 0.02); the odds ratios increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week: AL: OR = 1.6 [1.2–2.1], lymphoblastic AL: OR = 1.5 [1.1–2.0], myeloblastic AL: OR = 2.4 [1.3–4.3]). The association was slightly more marked for children born to non-smoking mothers. Lymphoblastic AL was also associated with cola soda drinking (OR = 1.3 [1.0–1.5], p = 0.02). No significant gene–environment interactions with coffee, tea, cola soda, or alcohol drinking were observed.

Conclusion

This study provides additional evidence that maternal coffee consumption during pregnancy may be associated with childhood AL. Coffee consumption is a prevalent habit and its potential involvement in childhood AL needs to be considered further.

Keywords

Childhood leukemia Coffee Alcohol Pregnancy Gene Interaction