Cancer Causes & Control

, Volume 24, Issue 4, pp 783–793

Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms

  • Audrey Bonaventure
  • Jérémie Rudant
  • Stéphanie Goujon-Bellec
  • Laurent Orsi
  • Guy Leverger
  • André Baruchel
  • Yves Bertrand
  • Brigitte Nelken
  • Marlène Pasquet
  • Gérard Michel
  • Nicolas Sirvent
  • Pierre Bordigoni
  • Stéphane Ducassou
  • Xavier Rialland
  • Diana Zelenika
  • Denis Hémon
  • Jacqueline Clavel
Original paper

DOI: 10.1007/s10552-013-0161-9

Cite this article as:
Bonaventure, A., Rudant, J., Goujon-Bellec, S. et al. Cancer Causes Control (2013) 24: 783. doi:10.1007/s10552-013-0161-9

Abstract

Purpose

This study aimed to analyze the associations between childhood acute leukemia (AL) and maternal caffeinated beverage consumption during pregnancy, and to explore interactions between caffeinated and alcoholic beverage consumption and polymorphisms of enzymes involved in caffeine and ethanol metabolisms.

Methods

The data were generated by the French ESCALE study, which included 764 AL cases and 1,681 controls in 2003–2004. The case and control mothers were interviewed on their consumption habits during pregnancy using a standardized questionnaire. Genotypes of the candidate alleles (NAT2*5 rs1801280, ADH1C*2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867) were obtained using high-throughput genotyping and imputation data for 493 AL cases and 549 controls with at least two grandparents born in Europe.

Results

Maternal regular coffee consumption during pregnancy was associated with childhood AL (OR = 1.2 [1.0–1.5], p = 0.02); the odds ratios increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week: AL: OR = 1.6 [1.2–2.1], lymphoblastic AL: OR = 1.5 [1.1–2.0], myeloblastic AL: OR = 2.4 [1.3–4.3]). The association was slightly more marked for children born to non-smoking mothers. Lymphoblastic AL was also associated with cola soda drinking (OR = 1.3 [1.0–1.5], p = 0.02). No significant gene–environment interactions with coffee, tea, cola soda, or alcohol drinking were observed.

Conclusion

This study provides additional evidence that maternal coffee consumption during pregnancy may be associated with childhood AL. Coffee consumption is a prevalent habit and its potential involvement in childhood AL needs to be considered further.

Keywords

Childhood leukemiaCoffeeAlcoholPregnancyGeneInteraction

Abbreviations

AL

Acute leukemia

ALL

Acute lymphoblastic leukemia

AML

Acute myeloblastic leukemia

CEU

Utah residents with Northern and Western European ancestry from the CEPH collection

CEPH

Centre d’Etude du Polymorphisme Humain

CYP2E1

Cytochrome P450 2E1

NAT2

N-acetyltransferase 2

ADH

Alcohol dehydrogenase

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Audrey Bonaventure
    • 1
    • 2
  • Jérémie Rudant
    • 1
    • 2
    • 3
  • Stéphanie Goujon-Bellec
    • 1
    • 2
    • 3
  • Laurent Orsi
    • 1
    • 2
  • Guy Leverger
    • 4
    • 5
  • André Baruchel
    • 6
    • 7
  • Yves Bertrand
    • 8
  • Brigitte Nelken
    • 9
    • 10
  • Marlène Pasquet
    • 11
  • Gérard Michel
    • 12
  • Nicolas Sirvent
    • 13
  • Pierre Bordigoni
    • 14
  • Stéphane Ducassou
    • 15
  • Xavier Rialland
    • 16
    • 17
  • Diana Zelenika
    • 18
  • Denis Hémon
    • 1
    • 2
  • Jacqueline Clavel
    • 1
    • 2
    • 3
  1. 1.Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer GroupVillejuifFrance
  2. 2.Univ Paris-Sud, UMRS 1018VillejuifFrance
  3. 3.RNHE, National Registry of Childhood Hematopoietic MalignanciesVillejuifFrance
  4. 4.AP-HP, Hôpital Armand TrousseauParisFrance
  5. 5.Université Paris 6 Pierre et Marie CurieParisFrance
  6. 6.AP-HP, Hôpital Robert DebréParisFrance
  7. 7.Université Paris 7ParisFrance
  8. 8.Institut d’Hémato-Oncologie PédiatriqueLyonFrance
  9. 9.Hôpital Jeanne de Flandre, CHRULilleFrance
  10. 10.Université Lille Nord de FranceLilleFrance
  11. 11.Hôpital des EnfantsToulouseFrance
  12. 12.AP-HM, Hôpital la TimoneMarseilleFrance
  13. 13.Hôpital Arnaud de VilleneuveMontpellierFrance
  14. 14.CHU de NancyVandoeuvreFrance
  15. 15.Hematology and Oncology, Children’s Hospital, PellegrinBordeaux University HospitalBordeauxFrance
  16. 16.Hôpital Mère-Enfant, CHU-NantesNantesFrance
  17. 17.CHU d’AngersAngersFrance
  18. 18.Commissariat à l’Energie Atomique (CEA) Genomics Institute-Centre National de GénotypageEvry CedexFrance