Original paper

Cancer Causes & Control

, Volume 24, Issue 3, pp 495-504

Serum 25-hydroxyvitamin D and breast cancer in the military: a case–control study utilizing pre-diagnostic serum

  • Sharif B. MohrAffiliated withDivision of Epidemiology, Department of Family and Preventive Medicine, University of California San DiegoNaval Health Research Center Email author 
  • , Edward D. GorhamAffiliated withDivision of Epidemiology, Department of Family and Preventive Medicine, University of California San DiegoNaval Health Research Center
  • , John E. AlcarazAffiliated withDepartment of Epidemiology and Biostatistics, San Diego State University
  • , Christopher I. KaneAffiliated withDivision of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego
  • , Caroline A. MaceraAffiliated withDepartment of Epidemiology and Biostatistics, San Diego State University
  • , J. Kellogg ParsonsAffiliated withDepartment of Surgery, University of California San Diego
  • , Deborah L. WingardAffiliated withDivision of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego
  • , Ronald HorstAffiliated withHeartland Assays
  • , Cedric F. GarlandAffiliated withDivision of Epidemiology, Department of Family and Preventive Medicine, University of California San DiegoNaval Health Research Center

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Abstract

Purpose

The objective of this study was to ascertain whether a relationship exists between pre-diagnostic serum levels of 25-hydroxyvitamin D (25(OH)D) and risk of breast cancer in young women.

Methods

About 600 incident cases of breast cancer were matched to 600 controls as part of a nested case–control study that utilized pre-diagnostic sera. Logistic regression was used to assess the relationship between serum 25(OH)D concentration and breast cancer risk, controlling for race and age.

Results

According to the conditional logistic regression for all subjects, odds ratios for breast cancer by quintile of serum 25(OH)D from lowest to highest were 1.2, 1.0, 0.9, 1.1, and 1.0 (reference) (p trend = 0.72). After multivariate regression for subjects whose blood had been collected within 90 days preceding diagnosis, odds ratios for breast cancer by quintile of serum 25(OH)D from lowest to highest were 3.3, 1.9, 1.7, 2.6, and 1.0 (reference) (p trend = 0.09).

Conclusions

An inverse association between serum 25(OH)D concentration and risk of breast cancer was not present in the principal analysis, although an inverse association was present in a small subgroup analysis of subjects whose blood had been collected within 90 days preceding diagnosis. Further prospective studies of 25(OH)D and breast cancer risk are needed.

Keywords

Vitamin D Breast neoplasms Case–control studies 25-hyrdoxyvitamin D Epidemiology