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A meta-analysis of coffee and tea consumption and the risk of glioma in adults

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Abstract

Background

Coffee contains many compounds, including antioxidants, which could prevent cancerogenesis, and coffee has been related with lower incidence of cancer at several sites. Tea is also rich in antioxidants, mainly polyphenols. To provide a quantitative overall estimate on the relation between coffee and tea consumption and glioma, we combined all published data, using a meta-analytic approach.

Methods

In September 2012, a bibliography search was carried out in both PubMed and Embase to identify observational studies providing quantitative estimates on the issue. Pooled estimates of the relative risks (RR) and the corresponding 95 % confidence intervals (CI) were calculated using random-effects models.

Results

Six studies (four cohort and two case–control studies) were available for meta-analysis, for a total of about 2100 cases. The summary RRs and 95 % CIs of glioma for drinkers versus non/occasional drinkers were 0.96 (95 % CI: 0.81–1.13) for coffee and 0.86 (95 % CI: 0.78–0.94) for tea, with no heterogeneity between studies. When we compared the highest versus the lowest categories of consumption, the RRs were 1.01 (95 % CI: 0.83–1.22) for coffee, 0.88 (95 % CI: 0.69–1.12) for tea, and 0.75 (95 % CI: 0.54–1.05) for coffee plus tea.

Conclusions

This meta-analysis, although based on few studies, suggests a lack of association between coffee intake and glioma risk, and a tendency, if any, to a lower risk for tea and coffee plus tea drinkers.

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Acknowledgments

The authors thank Mrs. I. Garimoldi for editorial assistance.

Conflict of interest

The authors declare no conflict of interest. This work was conducted with the contribution of the Italian Association for Cancer Research (AIRC), project No. 10068. CG was supported by Fondazione Umberto Veronesi. SM and FT were supported by a fellowship from the Italian Foundation for Cancer Research

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Authors and Affiliations

  1. Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 0157, Milan, Italy

    Stefano Malerba, Carlotta Galeone, Claudio Pelucchi, Federica Turati, Carlo La Vecchia & Alessandra Tavani

  2. Department of Occupational Health Clinica del Lavoro Luigi Devoto, University of Milan, Milan, Italy

    Federica Turati & Carlo La Vecchia

  3. Division of Public Health, Department of Family and Preventive Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA

    Mia Hashibe

Authors
  1. Stefano Malerba
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  2. Carlotta Galeone
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  3. Claudio Pelucchi
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  4. Federica Turati
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  5. Mia Hashibe
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  6. Carlo La Vecchia
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  7. Alessandra Tavani
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Corresponding author

Correspondence to Carlotta Galeone.

Additional information

Stefano Malerba and Carlotta Galeone contributed equally to this work and are considered co-first authors.

Appendix 1

Appendix 1

(case–control OR cohort OR epidemiolog*) AND (cancer OR carcinoma OR neoplasms OR tumor OR tumour) AND (coffee OR caffeine OR beverages OR diet OR drinking OR tea OR decaf*) AND (brain OR cerebral OR intracranial OR glioma OR meningioma OR glioblastoma OR astrocytoma OR neuroblastoma OR central nervous system OR schwannoma).

for PubMed and.

‘case control’ OR cohort OR ‘epidemiology’/exp OR epidemiology AND (coffee OR ‘decaf’/exp OR beverages OR diet OR tea OR caffeine) AND (‘acoustic neuroma’/exp OR ‘astrocytoma’/exp OR ‘chordoma’/exp OR ‘cns lymphoma’ OR ‘craniopharyngioma’/exp OR ‘glioma’/exp OR ‘schwannoma’/exp OR ‘pineal’ OR ‘rhabdoid’ OR ‘pituitary’/exp OR ‘primitive neuroectodermal’ OR ‘pnet’ OR ‘ependymoma’/exp OR ‘subependymoma’/exp OR ‘oligodendroglioma’/exp OR ‘meningioma’/exp OR ‘metastatic’ OR ‘medulloblastoma’/exp OR ‘brain tumor’/exp OR ‘intercranial tumor’ OR ‘brain tumour’/exp OR ‘intracranial tumour’ OR ‘brain neoplasms’/exp OR ‘intracranial neoplasms’ OR ‘brain cancer’/exp OR ‘intracranial cancer’) for Embase.

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Malerba, S., Galeone, C., Pelucchi, C. et al. A meta-analysis of coffee and tea consumption and the risk of glioma in adults . Cancer Causes Control 24, 267–276 (2013). https://doi.org/10.1007/s10552-012-0126-4

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  • DOI: https://doi.org/10.1007/s10552-012-0126-4

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