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A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis

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Abstract

Purpose

The association between marital status and tumor stage and grade, as well as overall mortality (OM) and cancer-specific mortality (CSM) received little attention in patients with squamous cell carcinoma of the penis (SCCP).

Methods

We relied on the surveillance, epidemiology, and end results (SEER) 17 database to identify patients diagnosed with primary SCCP. Logistic and Cox regression models, respectively, addressed the effect of marital status on the rate of locally advanced disease and its effect on OM and CSM. Covariates consisted of age, race, socioeconomic status, year of surgery, and SEER registries.

Results

Between 1988 and 2006, 1,884 patients with SCCP were identified. At surgery, 1,192 (63.3 %) were married and 966 (51.3 %) had locally advanced disease. In multivariable logistic regression models predicting locally advanced disease at surgery, unmarried men had a 1.5-fold higher (p < 0.001) risk than others. In multivariable Cox models predicting CSM, marital status had no effect [hazard ratio (HR) = 1.3, p = 0.1]. Finally, in multivariable Cox models predicting OM, unmarried men had a 1.3-fold higher (p = 0.001) risk than others.

Conclusion

Unmarried men tend to present with less favorable disease stage at SCCP. Moreover, unmarried men tend to live less long than their married counterparts. However, marital status has no effect on CSM.

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Acknowledgments

Pierre I. Karakiewicz is partially supported by the University of Montreal Health Center Urology Specialists, Fonds de la Recherche en Santé du Quebec, the University of Montreal Department Of Surgery and the University of Montreal Health Center (CHUM) Foundation. Rodolphe Thuret is partially supported by the Association Française d’Urologie (AFU).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Canada

    Rodolphe Thuret, Maxine Sun, Lars Budaus, Firas Abdollah, Daniel Liberman & Pierre I. Karakiewicz

  2. Department of Urology, Montpellier University, Montpellier, France

    Rodolphe Thuret, Lars Budaus, Firas Abdollah, Daniel Liberman, François Iborra, Jacques Guiter & Pierre I. Karakiewicz

  3. Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany

    Lars Budaus, Firas Abdollah, Daniel Liberman & Pierre I. Karakiewicz

  4. Department of Urology, Vita-Salute San Raffaele University, Milan, Italy

    Firas Abdollah, Daniel Liberman & Pierre I. Karakiewicz

  5. Department of Urology, University of Montreal, Montreal, Canada

    Daniel Liberman, Paul Perrotte & Pierre I. Karakiewicz

  6. Department of Urology, Weill Medical College of Cornell University, New York, USA

    Shahrokh F. Shariat

  7. Department of Urology, Kremlin-Bicetre’s Hospital, Paris, France

    Jean-Jacques Patard

Authors
  1. Rodolphe Thuret
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  2. Maxine Sun
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  3. Lars Budaus
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  4. Firas Abdollah
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  5. Daniel Liberman
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  6. Shahrokh F. Shariat
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  7. François Iborra
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  8. Jacques Guiter
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  9. Jean-Jacques Patard
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  10. Paul Perrotte
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  11. Pierre I. Karakiewicz
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Corresponding author

Correspondence to Rodolphe Thuret.

Additional information

Rodolphe Thuret and Maxine Sun contributed equally to this work.

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Thuret, R., Sun, M., Budaus, L. et al. A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis. Cancer Causes Control 24, 71–79 (2013). https://doi.org/10.1007/s10552-012-0091-y

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  • DOI: https://doi.org/10.1007/s10552-012-0091-y

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