Perinatal characteristics and retinoblastoma
- Julia E. HeckAffiliated withDepartment of Epidemiology, Fielding School of Public Health, University of California Email author
- , Christina A. LombardiAffiliated withDepartment of Epidemiology, Fielding School of Public Health, University of California
- , Travis J. MeyersAffiliated withDepartment of Epidemiology, Fielding School of Public Health, University of California
- , Myles CockburnAffiliated withDepartment of Preventive Medicine, USC/Keck School of Medicine
- , Michelle WilhelmAffiliated withDepartment of Epidemiology, Fielding School of Public Health, University of California
- , Beate RitzAffiliated withDepartment of Epidemiology, Fielding School of Public Health, University of California
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The etiology of retinoblastoma remains poorly understood. In the present study, we examined associations between perinatal factors and retinoblastoma risk in California children.
We identified 609 retinoblastoma cases (420 unilateral, 187 bilateral, and 2 with laterality unknown) from California Cancer Registry records of diagnoses 1988–2007 among children < 6 years of age. We randomly selected 209,051 controls from California birth rolls. The source of most study data was birth certificates. Multivariable logistic regression was used to examine associations between retinoblastoma and perinatal characteristics.
Bilateral retinoblastoma was associated with greater paternal age [for fathers over 35, crude odds ratio (OR) = 1.73, 95 % confidence interval (CI) 1.20, 2.47] and with twin births (OR = 1.93, 95 % CI 0.99, 3.79). Among unilateral cases, we observed an increased risk among children of US-born Hispanic mothers (OR = 1.34, 95 % CI 1.01, 1.77) while a decreased risk was observed for infants born to mothers with less than 9 years of education (OR = 0.70, 95 % CI 0.49, 1.00), a group that consisted primarily of mothers born in Mexico. We observed that maternal infection in pregnancy with any STD (OR = 3.59, 95 % CI 1.58, 8.15) was associated with bilateral retinoblastoma.
This study supports the findings of previous investigations reporting associations between parental age, HPV infection, and retinoblastoma.
KeywordsAnemia Assisted reproductive techniques Human papillomavirus Mexican Americans Rhesus blood group system Risk factors Social class
- Perinatal characteristics and retinoblastoma
Cancer Causes & Control
Volume 23, Issue 9 , pp 1567-1575
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- Print ISSN
- Online ISSN
- Springer Netherlands
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- Assisted reproductive techniques
- Human papillomavirus
- Mexican Americans
- Rhesus blood group system
- Risk factors
- Social class
- Industry Sectors
- Author Affiliations
- 1. Department of Epidemiology, Fielding School of Public Health, University of California, Box 951772, 650 Charles E. Young Drive, Los Angeles, CA, 90095-1772, USA
- 2. Department of Preventive Medicine, USC/Keck School of Medicine, Los Angeles, CA, USA