Cancer Causes & Control

, Volume 21, Issue 10, pp 1533–1544

Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study

  • Lena Maria Nilsson
  • Ingegerd Johansson
  • Per Lenner
  • Bernt Lindahl
  • Bethany Van Guelpen
Original paper

DOI: 10.1007/s10552-010-9582-x

Cite this article as:
Nilsson, L.M., Johansson, I., Lenner, P. et al. Cancer Causes Control (2010) 21: 1533. doi:10.1007/s10552-010-9582-x

Abstract

Background

Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer.

Methods

Subjects were from the Västerbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15 years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression.

Results

No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee ≥4 versus <1 occasions/day was associated with a reduced risk (HR = 0.52, CI = 0.30–0.88, ptrend = 0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HRpremenopausal = 1.69, CI = 0.96–2.98, ptrend = 0.015, HRpostmenopausal = 0.60, CI = 0.39–0.93, ptrend = 0.006) and filtered coffee (HRpremenopausal = 1.76, CI = 1.04–3.00, ptrend = 0.045, HRpostmenopausal = 0.52, CI = 0.30–0.88, ptrend = 0.045). Boiled coffee was positively associated with the risk of respiratory tract cancer (HR = 1.81, CI = 1.06–3.08, ptrend = 0.084), a finding limited to men. Main results for less common cancer types included total coffee in renal cell cancer (HR = 0.30, CI = 0.11–0.79, ptrend = 0.009) and boiled coffee in pancreas cancer (HR = 2.51 CI = 1.15–5.50, ptrend = 0.006).

Conclusion

These findings demonstrate, for the first time, the potential relevance of brewing method in investigations of coffee consumption and cancer risk, but they must be confirmed in future studies.

Keywords

CancerCoffeeCaffeineRisk factorsBrewing method

Abbreviations

BMI

Body mass index

CI

Confidence interval

FFQ

Food frequency questionnaire

HR

Hazard ratio

ICD7

International Classification of Diseases, Revision 7

n

Number

PLS

Partial least square

VIP

The Västerbotten Intervention Project

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Lena Maria Nilsson
    • 1
  • Ingegerd Johansson
    • 2
  • Per Lenner
    • 3
  • Bernt Lindahl
    • 4
  • Bethany Van Guelpen
    • 5
  1. 1.Department of Public Health and Clinical Medicine, Nutritional ResearchUmeå UniversityUmeåSweden
  2. 2.Department of OdontologyUmeå UniversityUmeåSweden
  3. 3.Department of Oncology and Radiation Sciences, Oncological CenterUmeå UniversityUmeåSweden
  4. 4.Department of Public Health and Clinical Medicine, Occupational and Environmental MedicineUmeå UniversityUmeåSweden
  5. 5.Department of Medical Biosciences, PathologyUmeå UniversityUmeåSweden