Cancer Causes & Control

, Volume 21, Issue 6, pp 871–877

Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study

  • Matthew R. Bonner
  • Brent A. Williams
  • Jennifer A. Rusiecki
  • Aaron Blair
  • Laura E. Beane Freeman
  • Jane A. Hoppin
  • Mustafa Dosemeci
  • Jay Lubin
  • Dale P. Sandler
  • Michael C. R. Alavanja
Original paper

DOI: 10.1007/s10552-010-9514-9

Cite this article as:
Bonner, M.R., Williams, B.A., Rusiecki, J.A. et al. Cancer Causes Control (2010) 21: 871. doi:10.1007/s10552-010-9514-9
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Abstract

Objective

Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer.

Methods

The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days) × (exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders.

Results

Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06–1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HRhighest tertile = 1.21; 95% CI = 0.99–1.47) and lung (HRmiddle tertile = 1.45; 95% CI = 0.95–2.22) and leukemia (HRmiddle tertile = 2.38; 95% CI = 1.35–4.21) and non-Hodgkin’s lymphoma (HRmiddle tertile = 1.94; 95% CI = 1.16–3.22), although the exposure–response gradients were non-monotonic and p for trends were not significant.

Conclusion

We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos.

Keywords

Cancer incidenceTerbufosOrganophosphate insecticides

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Matthew R. Bonner
    • 1
  • Brent A. Williams
    • 1
  • Jennifer A. Rusiecki
    • 2
  • Aaron Blair
    • 3
  • Laura E. Beane Freeman
    • 3
  • Jane A. Hoppin
    • 4
  • Mustafa Dosemeci
    • 3
  • Jay Lubin
    • 5
  • Dale P. Sandler
    • 4
  • Michael C. R. Alavanja
    • 3
  1. 1.Department of Social and Preventive Medicine, School of Public Health and Health ProfessionsUniversity at BuffaloBuffaloUSA
  2. 2.Department of Preventive Medicine and BiometricsUniformed Services University of the Health SciencesBethesdaUSA
  3. 3.Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDepartment of Health and Human ServicesBethesdaUSA
  4. 4.Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of HealthDepartment of Health and Human ServicesResearch Triangle ParkUSA
  5. 5.Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDepartment of Health and Human ServicesBethesdaUSA