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Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors

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Abstract

Evidence suggests that exercise affects breast cancer risk and outcomes, but little is known about the mechanisms through which this effect may be mediated. This study examines the impact of exercise upon levels of adiponectin, high molecular weight adiponectin (HMWA), and leptin in breast cancer survivors.

Methods

One hundred and one sedentary, overweight breast cancer survivors were randomized to a 16-week exercise intervention or usual care control group. Anthropometric measurements were taken and fasting levels of adiponectin, HMWA and leptin were collected at baseline and 16 weeks.

Results

Baseline and week-16 measurements were available for 81 patients. The exercise group experienced a significant decrease in hip measurements, with no change in weight or body composition. There were no significant changes in adiponectin, HMWA, or leptin in either group. Modeling analyses demonstrated a significant inverse relationship between changes in leptin and adiponectin, but no relationship between changes in BMI, waist or hip circumference, or body fat percentage and change in leptin or adiponectin.

Conclusions

This study did not demonstrate a significant change in adipocytokine levels in breast cancer survivors participating in an exercise intervention, suggesting that further work is needed to explore the mechanisms through which exercise may impact breast cancer.

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Acknowledgments

We would like to thank Kristie Adloff, Stacy Kennedy, Christine Donovan, Christine Long, Kathianne Sellars, Pam Beaton, and the staff at the FitCorp Boston for their invaluable assistance in the exercise-training portion of this study. Dr. Mantzoros is supported by the American Institute of Cancer Research, NIH grants DK58785, DK79929, DK 081913, DK58845 and a discretionary grant from the Beth Israel-Deaconess Medical Center.

Research Support

American Society of Clinical Oncology, Lance Armstrong Foundation.

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Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA, 02115, USA

    Jennifer A. Ligibel, Anita Giobbie-Hurder, Nancy Campbell, Taylor Salinardi & Eric P. Winer

  2. Beth Israel Hospital, Harvard Medical School, 44 Binney Street, Boston, MA, 02115, USA

    Deanna Olenczuk & Christos S. Mantzoros

Authors
  1. Jennifer A. Ligibel
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  2. Anita Giobbie-Hurder
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  3. Deanna Olenczuk
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  4. Nancy Campbell
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  5. Taylor Salinardi
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  6. Eric P. Winer
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  7. Christos S. Mantzoros
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Corresponding author

Correspondence to Jennifer A. Ligibel.

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Ligibel, J.A., Giobbie-Hurder, A., Olenczuk, D. et al. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes Control 20, 1523–1528 (2009). https://doi.org/10.1007/s10552-009-9358-3

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  • DOI: https://doi.org/10.1007/s10552-009-9358-3

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