Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California
- June M. ChanAffiliated withDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Urology, University of California San Francisco
- , Furong WangAffiliated withDepartment of Epidemiology and Biostatistics, University of California San Francisco
- , Elizabeth A. HollyAffiliated withDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Health Research and Policy, Stanford University Email author
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The associations between animal protein or fat and risk of pancreatic cancer have been reported previously with inconsistent results. A population-based case–control study of pancreatic cancer was conducted in the San Francisco Bay Area to examine these associations.
A semi-quantitative food-frequency questionnaire was administered to 532 cases and 1,701 controls between 1995 and 1999. Odds ratios (OR) and 95% confidence intervals (CI) were computed as estimates of the relative risk of pancreatic cancer.
When comparing highest versus lowest levels of intake in multivariable adjusted models, positive associations were observed for several beef/lamb and individual animal protein items, including beef/lamb as a main dish (OR = 2.2, 95% CI: 1.0–4.5), regular hamburger (OR = 1.7, 95% CI: 1.2–2.4), whole eggs (OR = 1.6, 95% CI: 1.0–2.4), butter (OR = 2.4, 95% CI: 1.6–3.5), and total dairy not including butter (OR = 2.6, 95% CI: 1.8–3.7). Some high-fat/processed-meat products (i.e., sausage, salami, bacon), but not all (i.e., beef, pork, or poultry hot dogs), also were positively associated with risk. An inverse association was noted for greater chicken/turkey consumption (OR = 0.7, 95% CI: 0.5–1.0). The risk comparing the highest versus lowest quartiles for fats and cholesterol consumption were: total fat (OR = 1.6, 95% CI: 1.2–2.1); animal fat (OR = 1.9, 95% CI: 1.4–2.5); saturated fat (OR = 1.9, 95% CI: 1.4–2.6); monounsaturated fat (OR = 1.3, 95% CI: 1.0–1.8); and dietary cholesterol (OR = 1.5, 95% CI: 1.1–2.0, all p-trends ≤ 0.02).
These data provide some evidence that beef or lamb, eggs, dairy, fat, or cholesterol may increase the risk of pancreatic cancer.
KeywordsPancreatic neoplasm Case–control study Meat Dairy Fat
- Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California
Cancer Causes & Control
Volume 18, Issue 10 , pp 1153-1167
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- Springer Netherlands
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- Pancreatic neoplasm
- Case–control study
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- Author Affiliations
- 1. Department of Epidemiology and Biostatistics, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA, 94118-1944, USA
- 2. Department of Urology, University of California San Francisco, San Francisco, CA, USA
- 3. Department of Health Research and Policy, Stanford University, Stanford, CA, USA