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Comparison of resection margin status after single or double radiopaque marker insertion for tumor localization in breast cancer patients receiving neoadjuvant chemotherapy

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Abstract

Purpose

Insertion of radiopaque markers is helpful for tumor localization in patients receiving neoadjuvant chemotherapy (NAC) followed by breast-conserving surgery (BCS). The aim of this retrospective study was to investigate the pathologic margin status in patients with single or double marker insertion.

Methods

We reviewed the records of 130 patients with marker insertion prior to NAC followed by BCS from January 2016 to September 2019. Under ultrasonography guidance, single or double markers were inserted to localize a tumor in the breast. The incidence of additional resection after frozen biopsy and re-excision after permanent pathologic diagnosis was analyzed.

Results

In a total of 130 patients, 104 had a single marker in the center of the tumor and 26 had double markers at the periphery of the tumor before NAC. Among 69 patients with residual invasive tumors after NAC, there was no difference in the additional resection rate after frozen biopsy (single vs. double markers; 14.3% vs. 38.5%, P = .059) or the re-excision rate after final pathologic diagnosis (0% vs. 7.7%, P = .188). After propensity score matching for tumor size and subtypes, the two groups showed no differences in the additional resection rate after frozen biopsy (7.7% vs. 19.2%, P = .139) or the re-excision rate (0% vs. 3.8%, P = .308). After a median follow-up of 19 months (range 8–48 months), local recurrence-free survival did not differ between the two groups (log-rank P = .456).

Conclusions

Number of inserted markers for tumor localization did not affect the pathologic margin status after BCS.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank the Department of Biostatistics, Yonsei University College of Medicine, for assistance in statistical analysis

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Surgery, Hanyang University College of Medicine, Seoul, South Korea

    Chihwan Cha

  2. Department of Surgery, Dongtan Sacred Heart Hospital Hallym University, Hwaseong, Gyeonggi, South Korea

    Janghee Lee

  3. Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul, South Korea

    Dooreh Kim, Soong June Bae, Sung Gwe Ahn & Joon Jeong

  4. Department of Surgery, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang, Gyeonggi, South Korea

    Soeun Park

  5. Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

    Na Lae Eun & Eun Ju Son

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  1. Chihwan Cha
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  2. Janghee Lee
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  3. Dooreh Kim
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Correspondence to Joon Jeong.

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Cha, C., Lee, J., Kim, D. et al. Comparison of resection margin status after single or double radiopaque marker insertion for tumor localization in breast cancer patients receiving neoadjuvant chemotherapy. Breast Cancer Res Treat 184, 797–803 (2020). https://doi.org/10.1007/s10549-020-05907-9

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  • DOI: https://doi.org/10.1007/s10549-020-05907-9

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