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A high frequency of PALB2 mutations in Jamaican patients with breast cancer

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Purpose

Jamaica is an island nation with one of the highest breast cancer incidence rates in the Caribbean (40/100,000 per year). The contribution of cancer susceptibility gene mutations to the burden of breast cancer in Jamaica has not yet been explored. We sought to determine the prevalence of germline mutations in BRCA1, BRCA2, and PALB2 in 179 unselected Jamaican women with breast cancer.

Methods

We sequenced the entire coding regions of BRCA1, BRCA2, and PALB2 for all the study subjects.

Results

Overall, 8 of 179 patients (4.5%) had a mutation in one of the three genes: one in BRCA1, two in BRCA2, and five in PALB2.

Conclusions

These data suggest that in addition to BRCA1 and BRCA2, PALB2 should be included in genetic testing for breast cancer patients in Jamaica.

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Funding

This study was supported by Susan G Komen for the Cure, Komen Wyoming Affiliate KG11-0017(JH). Dr. Akbari is supported by Canadian Cancer Society Research Institute.

Author information

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Jordan Lerner-Ellis

  2. Ontario Institute for Cancer Research, Toronto, ON, Canada

    Jordan Lerner-Ellis

  3. Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada

    Jordan Lerner-Ellis

  4. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada

    Jordan Lerner-Ellis

  5. Sylvester Cancer Center, University of Miami, Miami, FL, USA

    Talia Donenberg, Sophia George & Judith Hurley

  6. Women’s College Research Institute, Women’s College Hospital, 76 Grenville St.Room 6421, Toronto, ON, M5S 1B2, Canada

    Humayun Ahmed, Robert Royer, Shiyu Zhang, Steven Narod & Mohammad R. Akbari

  7. Institute of Medical Science, University of Toronto, Toronto, Canada

    Humayun Ahmed, Steven Narod & Mohammad R. Akbari

  8. University of the West Indies, Mona, Jamaica

    Gilian Wharfe, Sheray Chin & Dwight Lowe

  9. Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

    Steven Narod & Mohammad R. Akbari

Authors
  1. Jordan Lerner-Ellis
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  2. Talia Donenberg
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  3. Humayun Ahmed
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  4. Sophia George
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  5. Gilian Wharfe
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  6. Sheray Chin
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  7. Dwight Lowe
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  8. Robert Royer
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  9. Shiyu Zhang
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  10. Steven Narod
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  11. Judith Hurley
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  12. Mohammad R. Akbari
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Corresponding author

Correspondence to Mohammad R. Akbari.

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Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Cite this article

Lerner-Ellis, J., Donenberg, T., Ahmed, H. et al. A high frequency of PALB2 mutations in Jamaican patients with breast cancer. Breast Cancer Res Treat 162, 591–596 (2017). https://doi.org/10.1007/s10549-017-4148-1

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  • DOI: https://doi.org/10.1007/s10549-017-4148-1

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