Abstract
Purpose
To identify weak points in daily routine use of radiation therapy (RT) for non-metastatic breast cancer patients, particularly when data are lacking or equivocal, a “think tank” of experts met in Assisi.
Methods
Before the meeting, controversial issues on non-metastatic breast cancer were identified and reviewed, and clinical practice investigated by means of an online questionnaire. During the 3-day meeting, topics were discussed in-depth with attendees and potential sponsors that are involved in breast cancer treatment.
Results
Three issues were identified as needing further investigation: (1) Regional lymph node treatment in early-stage breast cancer; (2) Combined post-mastectomy RT and breast reconstruction; (3) RT in patients treated with primary systemic therapy. Future research proposals included the following: (1) Participating in appropriately selected on-going clinical trials; (2) Designing new randomized controlled clinical trials and prospective population cohort studies; (3) Setting-up large database(s) to generate predictive response models and detect biomarkers for tailored loco-regional treatments.
Conclusions
It is hoped that the ATTM findings, as described in the present white paper, will stimulate a new generation of radiation oncologists to focus on research in these areas, and that the white paper will become a tool for multidisciplinary groups to help them design research proposals and strategies.
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Abbreviations
- ATTM:
-
Assisi Think Tank Meeting
- ESTRO:
-
European Society for RadioTherapy & Oncology
- RT:
-
Radiation therapy
- PMRT:
-
Post-mastectomy radiation therapy
- PST:
-
Primary systemic therapy
- ALND:
-
Axillary lymph node dissection
- IBCSG:
-
International Breast Cancer Study Group
- SLN:
-
Sentinel lymph node
- ACOSOG:
-
American College of Surgeons Oncology Group
- EORTC:
-
European Organisation for Research and Treatment of Cancer
- DBCG-IMN:
-
Danish breast cancer cooperative group—internal mammary nodes
- EBCTCG:
-
Early Breast Cancer Trialists’ Collaborative Group
- IMRT:
-
Intensity-modulated radiation therapy
- pCR:
-
Pathological complete response
- CTNeoBC:
-
Collaborative Trials in Neoadjuvant Breast Cancer
- HER2:
-
Human Epidermal Growth Factor Receptor 2
- FNR:
-
False-negative rate
- SENTINA:
-
Sentinel-Lymph-Node Biopsy in Patients with Breast Cancer Before and After Neoadjuvant Chemotherapy
- MARI:
-
Marking axillary’s lymph node with radioactive iodine seed
- NSABP:
-
National Surgical Adjuvant Breast Project
- NCDB:
-
National Cancer Database
- ER:
-
Estrogen receptor
- PR:
-
Progesterone receptor
- AI:
-
Aromatase inhibitors
- FNA:
-
Fine-needle aspiration
- CNB:
-
Core needle biopsy
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Acknowledgments
The authors thank all the other ATTM Expert European Board members: Bruno Cutuli, Pierfrancesco Franco, Domenico Genovesi, Vladislav Grinberg, Diclehan Kilic, Vassilis Kouloulias, Lorenzo Livi, Stefano Maria Magrini, Fabio Marazzi, Icro Meattini, Angel Montero Luis, Isabella Palumbo, Elisabetta Perrucci, Luigi Pirtoli, Ugur Selek, Daniela Smaniotto, Fabrizio Stracci, Vincenzo Tombolini, Lurdes Trigo, Cristiana Vidali.
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The authors declare that they have no conflict of interest. Dr. Charlotte Coles is supported by the Cambridge National Institute of Health Research Biomedical Research Centre.
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Aristei, C., Kaidar-Person, O., Arenas, M. et al. The 2016 Assisi Think Tank Meeting on breast cancer: white paper. Breast Cancer Res Treat 160, 211–221 (2016). https://doi.org/10.1007/s10549-016-3998-2
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DOI: https://doi.org/10.1007/s10549-016-3998-2