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Bilateral breast cancer, synchronous and metachronous; differences and outcome

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Abstract

The aims of this study were twofold: to analyze the incidence of patients having synchronous or metachronous bilateral invasive breast cancer (SBBC and MBBC) and to assess the characteristics and outcome compared to those having unilateral breast cancer (UBC). The used data were obtained from our prospective population-based cohort study which had been started in 1983. Bilateral breast cancer (BBC) was categorized as SBBC (≤3 months of the first primary) or MBBC (>3 months after the first primary). The incidence of SBBC was 1 % and that of MBBC 7.0 %. Patients with UBC showed more ductal carcinoma compared to patients with BBC. MBBC status was an independent significant predictor of local failure (HR 1.9; 95 % CI 1.3–2.7). SBBC status was an independent predictor of distant metastases (HR 2.6; 95 % CI 1.4–4.5). Overall survival (OS) was better for MBBC (HR 0.6; 95 % CI 0.4–0.8) and worse for SBBC (HR 2.3; 95 % CI 1.5–3.6) compared to UBC. We noted: (1) MBBC showed a significant higher local failure compared to UBC, (2) SBBC, compared to MBBC and UBC had a significant higher distant metastases rate, (3) disease-specific survival and OS were significantly worse for SBBC compared to UBC and MBBC, and (4) that the OS for MBBC compared to UBC, was significantly better.

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References

  1. Soerjomataran I et al (2005) Risk of second primary breast and urogenital cancers following female breast cancer in the south of The Netherlands, 1972–2001. Eur J Cancer 41:2331–2337

    Article  Google Scholar 

  2. Lu W et al (2009) The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer. Eur J Cancer 45:3000–3007

    Article  PubMed  Google Scholar 

  3. Chen Y, Thompson W, Semenciw R et al (1999) Epidemiology of contralateral breast cancer. Cancer Epidemiol, Biomark Prev 8:855–861

    CAS  Google Scholar 

  4. Beinart G, Gonzalez-Angulo AM, Broglio K et al (2007) Clinical course of 771 patients with bilateral breast cancer: characteristics associated with overall and recurrence-free survival. Clin Breast Cancer 7:867–874

    Article  PubMed  Google Scholar 

  5. Kheirelseid EAH, Jumustafa H, Miller N et al (2011) Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics. Breast Cancer Res Treat 126:131–140

    Article  PubMed  Google Scholar 

  6. Quan G, Pommier SJ, Pommier RF (2008) Incidence and outcome of contralateral breast cancer. Am J Surg 195:645–650

    Article  PubMed  Google Scholar 

  7. Hartmann LC, Schaid DJ, Woods JE et al (1999) Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med 340:77–84

    Article  CAS  PubMed  Google Scholar 

  8. Bernstein JL, Lapinski RH, Thakore SS et al (2003) The descriptive epidemiology of second primary breast cancer. Epidemiology 14:552–558

    Article  PubMed  Google Scholar 

  9. Li CI, Malone KE, Porter PL et al (2003) Epidemiologic and molecular risk factors for contralateral breast cancer among young women. Br J Cancer 89:513–518

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Malone KE, Daling JR, Weiss NS et al (1996) Family history and survival of young women with invasive breast carcinoma. Cancer 78:1417–1425

    Article  CAS  PubMed  Google Scholar 

  11. Verkooijen HM, Chatelain V, Fiorettta G et al (2007) Survival after bilateral breast cancer: results from a population-based study. Breast Cancer Res Treat 105:347–357

    Article  PubMed  Google Scholar 

  12. Senkus E, Szada J, Pieczyriska B et al (2014) Are synchronous and metachronous bilateral breast cancers different? An immunohistochemical analysis aimed at intrinsic tumor phenotype. Int J Clin Exp Pathol 7:353–363

    PubMed Central  PubMed  Google Scholar 

  13. Shi YX, Xia Q, Peng RJ et al (2012) Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer. J Cancer Res Clin Oncol 138:705–714

    Article  PubMed  Google Scholar 

  14. Beckmann KR, Buckingham J, Craft P et al (2011) Clinical characteristics and outcome of bilateral breast cancer in an Australian cohort. Breast 20:158–164

    Article  CAS  PubMed  Google Scholar 

  15. Holm M, Tjonneland A, Balslev E et al (2014) Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. Breast Cancer Res Treat 146:461–475

    Article  PubMed  Google Scholar 

  16. Kwast ABG, Liu L, Roukema JA et al (2012) Increased risk of third primary cancers of non-breast origin among women with bilateral breast cancer. Br J Cancer 107:549–555

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Carmichael AR, Bendall S, Lockerbie L et al (2002) The long-term outcome of synchronous bilateral breast cancer is worse than metachronous of unilateral tumors. Eur J Surg Oncol 28:388–391

    Article  CAS  PubMed  Google Scholar 

  18. Heron DE, Komarnicky LT, Hyslop T et al (2000) Bilateral breast carcinoma. Risk factors and outcome for patients with synchronous and metachronous disease. Cancer 88:2739–2750

    Article  CAS  PubMed  Google Scholar 

  19. Roder D, De Silva P, Zorbas H et al (2012) Survival from synchronous bilateral breast cancer: the experience of surgeons participating in the Breast audit of the Society of Breast Surgeons of Australia and New Zealand. Asian Pac J Cancer Prev 13:1412–1418

    Google Scholar 

  20. Kolias J, Ellis IO, Elston CW et al (2001) Prognostic significance of synchronous and metachronous bilateral breast cancer. World J Surg 25:1117–1124

    Article  Google Scholar 

  21. Jobsen JJ, Van der Palen J, Ong F et al (2003) Synchronous bilateral breast cancer: prognostic value and incidence. The Breast 12:83–88

    Article  CAS  PubMed  Google Scholar 

  22. Polednak AP (2003) Bilateral synchronous breast cancer: a population-based study of characteristics, method of detection, and survival. Surgery 133:383–389

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands

    J. J. Jobsen & F. Ong

  2. Department of Research Methodology, Measurement, and Data Analysis, Faculty of Behavioural Science, University of Twente, Enschede, The Netherlands

    J. van der Palen

  3. Laboratorium Pathologie Oost Nederland, Hengelo, The Netherlands

    S. Riemersma

  4. Department of Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands

    H. Struikmans

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  1. J. J. Jobsen
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  2. J. van der Palen
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  3. F. Ong
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  4. S. Riemersma
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  5. H. Struikmans
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Correspondence to J. J. Jobsen.

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Jobsen, J.J., van der Palen, J., Ong, F. et al. Bilateral breast cancer, synchronous and metachronous; differences and outcome. Breast Cancer Res Treat 153, 277–283 (2015). https://doi.org/10.1007/s10549-015-3538-5

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  • DOI: https://doi.org/10.1007/s10549-015-3538-5

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