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A framework for the role of acute inflammation in tumor progression

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Abstract

Breast cancer remains the second leading cancer-related death in women in the United States. Despite improvements in early detection, prevention, and treatment, the mortality rate in breast cancer remains high secondary to the potential for cancer recurrence and the development of metastasis. To minimize breast cancer-related morbidity and mortality, understanding the factors leading to an increased risk of metastasis and developing clinical interventions that reduce this risk is essential. While the association between chronic inflammation and cancer progression is well documented in the literature, the role of acute inflammation and its impact on tumor proliferation and metastasis is less well understood. Here, we will review recently published preclinical studies in mouse models indicating that acute inflammation caused by clinical interventions plays an important role in the risk of peripheral metastases. In addition, we will address the potential impact that these findings may have on the clinical management of breast cancer.

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References

  1. Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1(8336):1273–1275

  2. Shiotani A, Cen P, Graham DY (2013) Eradication of gastric cancer is now both possible and practical. Semin Cancer Biol 23(6 Pt B):492–501. doi:10.1016/j.semcancer.2013.07.004

    Article  CAS  PubMed  Google Scholar 

  3. Brinkman JA, Caffrey AS, Muderspach LI, Roman LD, Kast WM (2005) The impact of anti HPV vaccination on cervical cancer incidence and HPV induced cervical lesions: consequences for clinical management. Eur J Gynaecol Oncol 26(2):129–142

    CAS  PubMed  Google Scholar 

  4. Durst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 80(12):3812–3815

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92(9):709–720

    Article  CAS  PubMed  Google Scholar 

  6. Kruger M, Hansen T, Kasaj A, Moergel M (2013) The correlation between chronic periodontitis and oral cancer. Case Rep Dent 2013:262410. doi:10.1155/2013/262410

    PubMed Central  PubMed  Google Scholar 

  7. Ullman TA, Itzkowitz SH (2011) Intestinal inflammation and cancer. Gastroenterology 140(6):1807–1816. doi:10.1053/j.gastro.2011.01.057

    Article  CAS  PubMed  Google Scholar 

  8. Terzic J, Grivennikov S, Karin E, Karin M (2010) Inflammation and colon cancer. Gastroenterology 138(6):2101–2114.e5. doi:10.1053/j.gastro.2010.01.058

    Article  CAS  PubMed  Google Scholar 

  9. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285–296. doi:10.1016/j.cell.2004.07.013

    Article  CAS  PubMed  Google Scholar 

  10. Qian BZ, Pollard JW (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141(1):39–51. doi:10.1016/j.cell.2010.03.014

    Article  CAS  PubMed  Google Scholar 

  11. Ruffell B, Affara NI, Coussens LM (2012) Differential macrophage programming in the tumor microenvironment. Trends Immunol 33(3):119–126. doi:10.1016/j.it.2011.12.001

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Palucka K, Coussens LM, O’Shaughnessy J (2013) Dendritic cells, inflammation, and breast cancer. Cancer J 19(6):511–516. doi:10.1097/ppo.0000000000000007

    Article  CAS  PubMed  Google Scholar 

  13. Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Terjanian T, Widmann WD (2012) Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 19(1):217–224. doi:10.1245/s10434-011-1814-0

    Article  PubMed  Google Scholar 

  14. Bellocq A, Antoine M, Flahault A, Philippe C, Crestani B, Bernaudin JF, Mayaud C, Milleron B, Baud L, Cadranel J (1998) Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. Am J Pathol 152(1):83–92

    PubMed Central  CAS  PubMed  Google Scholar 

  15. Medler TR, Coussens LM (2014) Duality of the immune response in cancer: lessons learned from skin. J Invest Dermatol 134(e1):E23–E28. doi:10.1038/skinbio.2014.5

    PubMed  Google Scholar 

  16. Chan CJ, Coussens LM (2013) Poker face no more: cancer recurrence reveals its hand. Nat Med 19(12):1569–1570. doi:10.1038/nm.3410

    Article  CAS  PubMed  Google Scholar 

  17. Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP (2003) Excisional surgery for cancer cure: therapy at a cost. Lancet Oncol 4(12):760–768

    Article  CAS  PubMed  Google Scholar 

  18. Walter ND, Rice PL, Redente EF, Kauvar EF, Lemond L, Aly T, Wanebo K, Chan ED (2011) Wound healing after trauma may predispose to lung cancer metastasis: review of potential mechanisms. Am J Respir Cell Mol Biol 44(5):591–596. doi:10.1165/rcmb.2010-0187RT

    Article  CAS  PubMed  Google Scholar 

  19. Sohn YM, Yoon JH, Kim EK, Moon HJ, Kim MJ (2014) Percutaneous ultrasound-guided vacuum-assisted removal versus surgery for breast lesions showing imaging-histology discordance after ultrasound-guided core-needle biopsy. Korean J Radiol 15(6):697–703. doi:10.3348/kjr.2014.15.6.697

    Article  PubMed Central  PubMed  Google Scholar 

  20. Biglia N, Ponzone R, Bounous VE, Mariani LL, Maggiorotto F, Benevelli C, Liberale V, Ottino MC, Sismondi P (2014) Role of re-excision for positive and close resection margins in patients treated with breast-conserving surgery. Breast 23(6):870–875. doi:10.1016/j.breast.2014.09.009

    Article  CAS  PubMed  Google Scholar 

  21. Russo AL, Arvold ND, Niemierko A, Wong N, Wong JS, Bellon JR, Punglia RS, Golshan M, Troyan SL, Brock JE, Harris JR (2013) Margin status and the risk of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy. Breast Cancer Res Treat 140(2):353–361. doi:10.1007/s10549-013-2627-6

    Article  CAS  PubMed  Google Scholar 

  22. Baum M, Demicheli R, Hrushesky W, Retsky M (2005) Does surgery unfavourably perturb the “natural history” of early breast cancer by accelerating the appearance of distant metastases? Eur J Cancer 41(4):508–515. doi:10.1016/j.ejca.2004.09.031

    Article  PubMed  Google Scholar 

  23. Bouchard G, Bouvette G, Therriault H, Bujold R, Saucier C, Paquette B (2013) Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. Br J Cancer 109(7):1829–1838. doi:10.1038/bjc.2013.502

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Guy CT, Cardiff RD, Muller WJ (1992) Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954–961

    PubMed Central  CAS  PubMed  Google Scholar 

  25. Hobson J, Gummadidala P, Silverstrim B, Grier D, Bunn J, James T, Rincon M (2013) Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis. Breast Cancer Res Treat 139(2):391–401. doi:10.1007/s10549-013-2575-1

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Retsky MW, Demicheli R, Hrushesky WJM, Forget P, DeKock M, Gukas I, Rogers RA, Baum M, Sukhatme V, Vaidya JS (2013) Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. Curr Med Chem 20(33):4163–4176

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors would like to acknowledge the Cabot Wellington Foundation and the VCC-LCCRO for supporting this research.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Western Connecticut Health Network, 24 Hospital Avenue, Danbury, CT, 06810, USA

    Gabriela Szalayova

  2. Department of Surgery, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA

    Ted A. James

  3. Department of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA

    Mercedes Rincon

Authors
  1. Gabriela Szalayova
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  2. Ted A. James
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  3. Mercedes Rincon
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Corresponding author

Correspondence to Ted A. James.

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Szalayova, G., James, T.A. & Rincon, M. A framework for the role of acute inflammation in tumor progression. Breast Cancer Res Treat 151, 235–238 (2015). https://doi.org/10.1007/s10549-015-3392-5

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  • DOI: https://doi.org/10.1007/s10549-015-3392-5

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