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Coexistence of breast cancer and tuberculosis in axillary lymph nodes: a case report and literature review

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Abstract

Coexistence of breast cancer and tuberculosis (TB) of the breast and/or axillary lymph nodes is uncommon. In this article, we present a case of tuberculous axillary lymphadenitis existing simultaneously with invasive ductal carcinoma of the left breast. We also conducted an extensive literature review of English language studies published on the coexistence of breast cancer and TB of the breast and/or axillary lymph nodes from 1899 to 2011 using the PubMed and Google Scholar databases. Twenty-nine cases of coexisting breast cancer and TB of the breast and/or axillary lymph nodes have been published to date, including a 74-year-old female diagnosed with left breast cancer and TB of the axillary lymph nodes. A tumor in the right breast was detected in 14 patients and in the left breast in 12 patients between the ages of 28 and 81 years, but no data were available regarding the side on which the tumor occurred in three patients. Eighteen patients underwent a modified radical mastectomy, five patients underwent a radical mastectomy, two a lumpectomy and an axillary lymph node dissection (ANLD), two a quadrantectomy (Q) and an ALND, and two an applied excision. TB was detected at the axilla in all 21 patients in patients with no TB of the breast, and TB was also detected in the axilla in five of eight patients with breast TB. Both a tumor and TB lymphadenitis were detected following an axillary dissection in 14 patients, and both cancer metastasis and TB lymphadenitis were detected at the same lymph nodes in six of these patients. The simultaneous occurrence of these two major illnesses in the breast and/or axillary lymph nodes can produce many problems with respect to diagnosis and treatment. Accurate diagnoses are necessary for down-staging carcinoma of the breast and for identifying curable disease.

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References

  1. Babu ED, Tariq N, Aref FA, Vashisht R (2004) Axillary gland involvement in breast carcinomas is not always metastatic: a case report. Int Surg 89(3):150–151

    PubMed  Google Scholar 

  2. Akbulut S, Yagmur Y, Bakir S, Sogutcu N, Yilmaz D, Senol A (2010) Appendicular tuberculosis: review of 155 published cases and a report of two cases. Eur J Trauma Emerg Surg 36:579–585

    Article  Google Scholar 

  3. Khan AH, Sulaiman SA, Muttalif AR, Hassali MA, Khan TM (2011) Tuberculous lymphadenitis at Penang General Hospital, Malaysia. Med Princ Pract 20(1):80–84

    Article  PubMed  Google Scholar 

  4. Huang SF, Li CP, Feng JY, Chao Y, Su WJ (2011) Increased risk of tuberculosis after gastrectomy and chemotherapy in gastric cancer: a 7-year cohort study. Gastric Cancer (in press)

  5. Salemis NS, Razou A (2010) Coexistence of breast cancer metastases and tuberculosis in axillary lymph nodes—a rare association and review of the literature. Southeast Asian J Trop Med Public Health 41(3):608–613

    PubMed  Google Scholar 

  6. Munjal K, Jain VK, Agrawal A, Bandi PK (2010) Coexisting tubercular axillary lymphadenitis wıth carcinoma breast can falsely over-stage the disease—case series. Indian J Tuberc 57(2):104–107

    PubMed  Google Scholar 

  7. Alzaraa A, Dalal N (2008) Coexistence of carcinoma and tuberculosis in one breast. World J Surg Oncol 6:29

    Article  PubMed  Google Scholar 

  8. Wani BN, Jajoo SN (2008) Ipsilateral axillary tubercular lymphadenopathy, contralateral osseous tuberculosis in a case of ductal carcinoma of breast. Indian J Cancer 45:182–184

    Article  PubMed  CAS  Google Scholar 

  9. Gaurav M, Rajgopal S, Mary M, Bhavatej E (2008) Concomitant tuberculosis and metastasis in axillary lymph nodes: a diagnostic surprise. ANZ J Surg 78(9):825–826

    Article  PubMed  Google Scholar 

  10. Broughton A, Galant C, Hainaut P (2008) Simultaneous occurrence of metastatic breast cancer, Hodgkin’s disease and tuberculous lymphadenitis in homolateral axillary lymph nodes–a case report. Acta Clin Belg 63(6):391–393

    PubMed  CAS  Google Scholar 

  11. Tulasi NR, Raju PC, Damodaran V, Radhika TS (2006) A spectrum of coexistent tuberculosis and carcinoma in the breast and axillary lymph nodes: report of five cases. Breast 15(3):437–439

    Article  PubMed  CAS  Google Scholar 

  12. Avninder SP, Saxena S (2006) Infiltrating ductal carcinoma of the breast, metastatic to axillary lymph nodes harboring primary tuberculous lymphadenitis. Pathol Oncol Res 12(3):188–189

    Article  PubMed  Google Scholar 

  13. Chottanapund S, Wongtawatchai P (2004) Tuberculous axillary lymphadenitis coexistence in patient with invasive ductal carcinoma of the breast: a case report. Thai J Surg 25:121–124

    Google Scholar 

  14. Fujii T, Kimura M, Yanagita Y, Koida T, Kuwano H (2003) Tuberculosis of axillary lymph nodes with primary breast cancer. Breast Cancer 10(2):175–178

    Article  PubMed  Google Scholar 

  15. Pandey M, Abraham EK, Chandramohan K, Rajan B (2003) Tuberculosis and metastatic carcinoma coexistence in axillary lymph node: a case report. World J Surg Oncol 1(1):3

    Article  PubMed  Google Scholar 

  16. Robinson AJ, Horne CA, Weaver A (2001) Coexistence of axillary tuberculous lymphadenitis with lymph node metastases from a breast carcinoma. Clin Oncol (R Coll Radiol) 13(2):144

    CAS  Google Scholar 

  17. Balasubramanian SP, Rao MP, Jayaram S, Bose SM (2001) Coexisting mammary tuberculosis and malignant disease. Can J Surg 44:224–225

    PubMed  CAS  Google Scholar 

  18. Cheng W, Alagaratnam TT, Chan ACL (1993) Tuberculosis and lymphoma of the breast in a patient with dermatomyositis. Aust NZ J Surg 63:660–661

    Article  CAS  Google Scholar 

  19. Das DK, Mohil RS, Kashyap V, Khan IU, Mandal AK, Gulati SM (1992) Colloid carcinoma of the breast with concomitant metastasis and a tuberculous lesion in the axillary lymph nodes. a case report. Acta Cytol 36(3):399–403

    PubMed  CAS  Google Scholar 

  20. Miller RE, Salomon PF, West JP (1971) The coexistence of carcinoma and tuberculosis of the breast and axillary lymph nodes. Am J Surg 121(3):338–340

    Article  PubMed  CAS  Google Scholar 

  21. Gregl A, Kienle J (1969) Axillary lymph node tuberculosis presenting lymphographic signs of metastasis from ipsilateral breast cancer. Radiology 93(5):1107–1108

    PubMed  CAS  Google Scholar 

  22. Smith LW, Mason RL (1926) The concurrence of tuberculosis and cancer of the breast. Surg Gynecol Obstet 43:70–72

    Google Scholar 

  23. Warthin AS (1899) The coexistence of tuberculosis and carcinoma of the mammary gland. Am J Med Sci 118:25

    Article  Google Scholar 

  24. Kaplan MH, Armstrong D, Rosen P (1974) Tuberculosis complicating neoplastic disease. a review of 201 cases. Cancer 33(3):850–858

    Article  PubMed  CAS  Google Scholar 

  25. Khurram M, Tariq M, Shahid P (2007) Breast cancer with associated granulomatous axillary lymphadenitis: a diagnostic and clinical dilemma in regions with high prevalence of tuberculosis. Pathol Res Pract 203(10):699–704

    Article  PubMed  CAS  Google Scholar 

  26. Kalaç N, Ozkan B, Bayiz H, Dursun AB, Demirağ F (2002) Breast tuberculosis. Breast 11(4):346–349

    Article  PubMed  Google Scholar 

  27. Akbulut S, Sogutcu N, Arikanoglu Z, Bakir S, Ulku A, Yagmur Y (2011) Thyroid tuberculosis in southeastern Turkey: is this the resurgence of a stubborn disease?. World J Surg (in press)

  28. Ilmer M, Bergauer F, Friese K, Mylonas I (2009) Genital tuberculosis as the cause of tuboovarian abscess in an immunosuppressed patient. Infect Dis Obstet Gynecol 2009:745060

    PubMed  CAS  Google Scholar 

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The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey

    Sami Akbulut & Yusuf Yagmur

  2. Department of Pathology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey

    Nilgun Sogutcu

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  1. Sami Akbulut
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  2. Nilgun Sogutcu
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  3. Yusuf Yagmur
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Correspondence to Sami Akbulut.

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Akbulut, S., Sogutcu, N. & Yagmur, Y. Coexistence of breast cancer and tuberculosis in axillary lymph nodes: a case report and literature review. Breast Cancer Res Treat 130, 1037–1042 (2011). https://doi.org/10.1007/s10549-011-1634-8

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  • DOI: https://doi.org/10.1007/s10549-011-1634-8

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