Breast Cancer Research and Treatment

, Volume 117, Issue 2, pp 417–422

Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity

  • Parviz Ghadirian
  • Steven Narod
  • Eve Fafard
  • Myriam Costa
  • André Robidoux
  • André Nkondjock
Epidemiology

DOI: 10.1007/s10549-008-0292-y

Cite this article as:
Ghadirian, P., Narod, S., Fafard, E. et al. Breast Cancer Res Treat (2009) 117: 417. doi:10.1007/s10549-008-0292-y

Abstract

It has been suggested that gene–environment interaction is related to the risk of cancer. To evaluate departure from multiplicative effects between BRCA mutations and diet diversity in breast cancer (BC), a case-only study was carried out in a French-Canadian population including 738 patients with incident primary BC comprising 38 BRCA mutation carriers. Diet diversity was assessed using a validated food frequency questionnaire. Unconditional logistic regression analysis was performed to assess case-only odds ratio (COR) and 95% confidence interval (CI) while adjusting for age, body mass index, smoking, hormonal replacement therapy, and total energy intake. Ours results reveal a strong and significant interaction between BRCA mutations and vegetable and fruit diversity (COR = 0.27; 95%CI = 0.10–0.80; P = 0.03) when comparing the upper to the lower quartiles. The estimates for departure from multiplicative effects between BRCA mutations and total or other food groups’ diversity were not supportive of the idea of a gene–environment interaction. The results of this study suggest that the combination of BRCA mutations and vegetable and fruit diversity may be associated with a reduced risk of BC.

Keywords

Breast cancerBRCADietFrench-CanadianVegetable and fruitCase-only study

Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Parviz Ghadirian
    • 1
  • Steven Narod
    • 2
  • Eve Fafard
    • 1
  • Myriam Costa
    • 1
  • André Robidoux
    • 3
    • 4
  • André Nkondjock
    • 5
    • 6
  1. 1.Epidemiology Research Unit, Research CentreCentre hospitalier de l’Université de Montréal (CHUM) Hôtel-DieuMontrealCanada
  2. 2.Canada Research Chair in Breast CancerCentre for Research in Women’s HealthTorontoCanada
  3. 3.Scotia Chair in Breast Cancer Diagnosis and TreatmentUniversité de MontréalMontrealCanada
  4. 4.Breast Cancer CentreCHUM-Hôtel-DieuMontrealCanada
  5. 5.Research Center for Military HealthYaoundeCameroon
  6. 6.Yaounde Military HospitalYaoundeCameroon