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Two-dimensional polyaniline nanostructure to the development of microfluidic integrated flexible biosensors for biomarker detection

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Abstract

In this work, we report a flexible field-effect-transistor (FET) biosensor design based on two-dimensional (2-D) polyaniline (PANI) nanostructure. The flexible biosensor devices were fabricated through a facile and inexpensive method that combines top-down and bottom-up processes. The chemically synthesized PANI nanostructure showed excellent p-type semiconductor properties as well as good compatibility with flexible design. With the 2-D PANI nanostructure being as thin as 80 nm and its extremely large surface-area-to-volume (SA/V) ratio due to the intrinsic properties of PANI chemical synthesis, the developed flexible biosensor exhibited outstanding sensing performance in detecting B-type natriuretic peptide (BNP) biomarkers, and was able to achieve high specificity (averagely 112 folds) with the limit of detection as low as 100 pg/mL. PANI nanostructure under bending condition was also investigated and showed controllable conductance changes being less than 20% with good restorability which may open up the possibility for wearable applications.

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Acknowledgements

The authors are grateful for partial financial support from the Central Research Development Fund at the University of Pittsburgh, and this work was partially supported by Institute for Basic Science (IBS), Korea.

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Correspondence to Seung Hee Lee or Minhee Yun.

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Liu, P., Zhu, Y., Lee, S.H. et al. Two-dimensional polyaniline nanostructure to the development of microfluidic integrated flexible biosensors for biomarker detection. Biomed Microdevices 18, 113 (2016). https://doi.org/10.1007/s10544-016-0142-3

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  • DOI: https://doi.org/10.1007/s10544-016-0142-3

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