Article

Biomedical Microdevices

, Volume 15, Issue 4, pp 665-671

Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer

  • Dokyoon KimAffiliated withDepartment of Materials Science and Engineering, Stanford University
  • , Jung-Rok LeeAffiliated withDepartment of Mechanical Engineering, Stanford University
  • , Eric ShenAffiliated withDepartment of Materials Science and Engineering, Stanford University
  • , Shan X. WangAffiliated withDepartment of Materials Science and Engineering, Stanford UniversityDepartment of Electrical Engineering, Stanford University Email author 

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Abstract

We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.

Keywords

Radiation biomarker Cancer biomarker Nanosensor Magnetic nanoparticles Immunoassay