Biomedical Microdevices

, Volume 15, Issue 4, pp 665–671

Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer

Authors

  • Dokyoon Kim
    • Department of Materials Science and EngineeringStanford University
  • Jung-Rok Lee
    • Department of Mechanical EngineeringStanford University
  • Eric Shen
    • Department of Materials Science and EngineeringStanford University
    • Department of Materials Science and EngineeringStanford University
    • Department of Electrical EngineeringStanford University
Article

DOI: 10.1007/s10544-012-9678-z

Cite this article as:
Kim, D., Lee, J., Shen, E. et al. Biomed Microdevices (2013) 15: 665. doi:10.1007/s10544-012-9678-z

Abstract

We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.

Keywords

Radiation biomarker Cancer biomarker Nanosensor Magnetic nanoparticles Immunoassay

Abbreviations

phosphor-SMC1

Phosphorylated-structural maintenance of chromosome 1

GCSF

Granulocyte colony stimulation factor

IL6

Interleukin-6

GMR

Giant magnetoresistance

MTJ

Magnetic tunnel junction

ELISA

Enzyme-linked immunosorbent assay

Copyright information

© Springer Science+Business Media, LLC 2012