Biomedical Microdevices

, Volume 13, Issue 3, pp 485–491

Micro-fabricated perforated polymer devices for long-term drug delivery

Authors

  • Zhuo-Jie Wu
    • Microelectronics Research CenterThe University of Texas at Austin
  • Zhiquan Luo
    • Microelectronics Research CenterThe University of Texas at Austin
  • Ashish Rastogia
    • Division of Pharmaceutics, College of PharmacyThe University of Texas at Austin
    • U.S. Army Institute of Surgical Research
  • Salomon Stavchansky
    • Division of Pharmaceutics, College of PharmacyThe University of Texas at Austin
  • Phillip D. Bowman
    • U.S. Army Institute of Surgical Research
    • Microelectronics Research CenterThe University of Texas at Austin
Article

DOI: 10.1007/s10544-011-9516-8

Cite this article as:
Wu, Z., Luo, Z., Rastogia, A. et al. Biomed Microdevices (2011) 13: 485. doi:10.1007/s10544-011-9516-8

Abstract

Fabrication techniques have been developed to produce a perforated polymer microtube as a drug delivery device. The technique consists of first forming a silicon platform with trenches and alignment marks to hold the tubes for subsequent processing. Photolithography and reactive ion etching with an inductively coupled plasma source were used to fabricate micro holes on the surface of polyimide tubes. Several materials have been used to form the etching mask, including titanium film deposited by e-beam evaporation and SiO2 and SiNx films deposited by high-density plasma chemical vapor deposition (HDPCVD). Three equidistant holes of 20 μm in diameter were fabricated on polyimide tubes (I.D. = 125 μm). The perforated tubes were loaded with ethinyl estradiol and tested for drug release in phosphate buffered saline (pH = 7.1) at 37°C. Zero order release was observed over a period of 30 days with a potential to be extended to 4 years.

Keywords

Drug delivery deviceMicrofabricationPolymer tubePolyimide

Copyright information

© Springer Science+Business Media, LLC 2011