Article

Biomedical Microdevices

, Volume 13, Issue 3, pp 485-491

Micro-fabricated perforated polymer devices for long-term drug delivery

  • Zhuo-Jie WuAffiliated withMicroelectronics Research Center, The University of Texas at Austin
  • , Zhiquan LuoAffiliated withMicroelectronics Research Center, The University of Texas at Austin
  • , Ashish RastogiaAffiliated withDivision of Pharmaceutics, College of Pharmacy, The University of Texas at AustinU.S. Army Institute of Surgical Research
  • , Salomon StavchanskyAffiliated withDivision of Pharmaceutics, College of Pharmacy, The University of Texas at Austin
  • , Phillip D. BowmanAffiliated withU.S. Army Institute of Surgical Research
  • , Paul S. HoAffiliated withMicroelectronics Research Center, The University of Texas at Austin Email author 

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Abstract

Fabrication techniques have been developed to produce a perforated polymer microtube as a drug delivery device. The technique consists of first forming a silicon platform with trenches and alignment marks to hold the tubes for subsequent processing. Photolithography and reactive ion etching with an inductively coupled plasma source were used to fabricate micro holes on the surface of polyimide tubes. Several materials have been used to form the etching mask, including titanium film deposited by e-beam evaporation and SiO2 and SiNx films deposited by high-density plasma chemical vapor deposition (HDPCVD). Three equidistant holes of 20 μm in diameter were fabricated on polyimide tubes (I.D. = 125 μm). The perforated tubes were loaded with ethinyl estradiol and tested for drug release in phosphate buffered saline (pH = 7.1) at 37°C. Zero order release was observed over a period of 30 days with a potential to be extended to 4 years.

Keywords

Drug delivery device Microfabrication Polymer tube Polyimide